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Journal of Clinical Oncology, Vol 21, Issue 24 (December), 2003: 4642-4649
© 2003 American Society for Clinical Oncology

SPECIAL ARTICLE

Revised Recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

Bruce D. Cheson, John M. Bennett, Kenneth J. Kopecky, Thomas Büchner, Cheryl L. Willman, Elihu H. Estey, Charles A. Schiffer, Hartmut Doehner, Martin S. Tallman, T. Andrew Lister, Francesco Lo-Coco, Roel Willemze, Andrea Biondi, Wolfgang Hiddemann, Richard A. Larson, Bob Löwenberg, Miguel A. Sanz, David R. Head, Ryuzo Ohno, Clara D. Bloomfield

From the Department of Hematology/Oncology, Georgetown University, Washington, DC; University of Rochester Medical Center, Rochester, NY; Fred Hutchinson Cancer Research Center, Seattle, WA; University of Texas M.D. Anderson Cancer Center, Houston, TX; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI; University of Münster, Münster; University of Grosshadern, Munich; University of Ulm, Ulm, Germany; University Tor Vergata of Rome; Clinica Pediatrica Università Milano-Bicocca, Ospedale S. Gerardo, Monza, Italy; Leiden University, Leiden; Erasmus Medical Center Rotterdam; Institute of Hematology, Rotterdam, Netherlands; University of Chicago; Northwestern University, Chicago, IL; Hospital Universitario La Fe, University of Valencia, Spain; University of New Mexico Cancer Treatment and Research Center, Albuquerque, NM; Aichi Cancer Center Hospital, Nagoya, Japan; St. Bartholomew’s Hospital, London, UK; Vanderbilt University School of Medicine, Nashville, TN; and The Ohio State University Comprehensive Cancer Center, Columbus, OH.

Address reprint requests to Bruce D. Cheson, MD, Head of Hematology, Georgetown University, Lombardi Cancer Center, 3800 Reservoir Rd, NW, Washington, DC 20007; e-mail: bdc4{at}georgetown.edu.

An International Working Group met to revise the diagnostic and response criteria for acute myelogenous leukemia originally published in 1990, as well as to provide definitions of outcomes and reporting standards to improve interpretability of data and comparisons among trials. Since the original publication, there have been major advances in our understanding of the biology and molecular genetics of acute leukemia that are clinically relevant and warrant incorporation into response definitions. Differences from the 1990 recommendations included a category of leukemia-free state, new criteria for complete remission, including cytogenetic and molecular remissions and remission duration. Storage of viable blasts for correlative studies is important for future progress in the therapy of these disorders.


Related Correspondence

  • Revised Recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
    U. Creutzig and G.J.L. Kaspers
    JCO 2004 22: 3432-3433 [Full Text]


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