Journal of Clinical Oncology, Vol 21, Issue 9
(May), 2003: 1660-1668
© 2003 American Society for Clinical Oncology
Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes
Kerry S. Courneya,
John R. Mackey,
Gordon J. Bell,
Lee W. Jones,
Catherine J. Field,
Adrian S. Fairey
From the Faculty of Physical Education, Faculty of Agriculture, Food, and Nutrition Sciences; and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
Address reprint requests to Kerry S. Courneya, PhD, Faculty of Physical Education, University of Alberta, E-424 Van Vliet Center, Edmonton, Alberta T6G 2H9, Canada; email: kerry.courneya{at}ualberta.ca.
Purpose: To determine the effects of exercise training on cardiopulmonary function and quality of life (QOL) in postmenopausal breast cancer survivors who had completed surgery, radiotherapy, and/or chemotherapy with or without current hormone therapy use.
Methods: Fifty-three postmenopausal breast cancer survivors were randomly assigned to an exercise (n = 25) or control (n = 28) group. The exercise group trained on cycle ergometers three times per week for 15 weeks at a power output that elicited the ventilatory equivalent for carbon dioxide. The control group did not train. The primary outcomes were changes in peak oxygen consumption and overall QOL from baseline to postintervention. Peak oxygen consumption was assessed by a graded exercise test using gas exchange analysis. Overall QOL was assessed by the Functional Assessment of Cancer Therapy–Breast scale.
Results: Fifty-two participants completed the trial. The exercise group completed 98.4% of the exercise sessions. Baseline values for peak oxygen consumption (P = .254) and overall QOL (P = .286) did not differ between groups. Peak oxygen consumption increased by 0.24 L/min in the exercise group, whereas it decreased by 0.05 L/min in the control group (mean difference, 0.29 L/min; 95% confidence interval [CI], 0.18 to 0.40; P < .001). Overall QOL increased by 9.1 points in the exercise group compared with 0.3 points in the control group (mean difference, 8.8 points; 95% CI, 3.6 to 14.0; P = .001). Pearson correlations indicated that change in peak oxygen consumption correlated with change in overall QOL (r = 0.45; P < .01).
Conclusion: Exercise training had beneficial effects on cardiopulmonary function and QOL in postmenopausal breast cancer survivors.
Supported by a Research Team Grant from the National Cancer Institute of Canada (NCIC) with funds from the Canadian Cancer Society (CCS) and the CCS/NCIC Sociobehavioral Cancer Research Network. K.S.C. is supported by an Investigator Award from the Canadian Institutes of Health Research. A.S.F. is supported by an Izaak Walton Killiam Memorial Scholarship. L.W.J. is supported by an Alberta Heritage Foundation for Medical Research studentship.
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