EDITORIALS

Promoter Hypermethylation: A New Therapeutic Target Emerges in Urothelial Cancer

Richard J. Cote, Peter W. Laird, and Ram H. Datar

JCO May 1 2005: 2879–2881. First published on Mar 7 2005; 10.1200/JCO.2005.11.923. [Full Text] [PDF]

Platinums in Lung Cancer: Sufficient or Necessary?

Paul A. Bunn, Jr

JCO May 1 2005: 2882–2883. First published on Feb 22 2005; 10.1200/JCO.2005.11.930. [Full Text] [PDF]

Treatment of Chronic Lymphocytic Leukemia: Achieving Minimal Residual Disease–Negative Status As a Goal

Emili Montserrat

JCO May 1 2005: 2884–2885. First published on Feb 28 2005; 10.1200/JCO.2005.11.932. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

Medicinal Cannabis in Oncology Practice: Still a Bridge Too Far?

Floris A. de Jong, Frederike K. Engels, Ron H.J. Mathijssen, Lia van Zuylen, Jaap Verweij, Remco P.H. Peters, and Alex Sparreboom

JCO May 1 2005: 2886–2891. [Full Text] [PDF]

Hepatocellular Carcinoma: The Need for Progress

Melanie B. Thomas and Andrew X. Zhu

JCO May 1 2005: 2892–2899. [Full Text] [PDF]

Type II Chemotherapy-Related Cardiac Dysfunction: Time to Recognize a New Entity

Michael S. Ewer and Scott M. Lippman

JCO May 1 2005: 2900–2902. [Full Text] [PDF]

ORIGINAL REPORTS
Genitourinary Cancer
	Promoter Hypermethylation Is Associated With Tumor Location, Stage, and Subsequent Progression in Transitional Cell Carcinoma
	James W.F. Catto, Abdel-Rahmene Azzouzi, Ishtiaq Rehman, Kenneth M. Feeley, Simon S. Cross, Najla Amira, Gaelle Fromont, Mathilde Sibony, Oliver Cussenot, Mark Meuth, and Freddie C. Hamdy
	JCO May 1 2005: 2903–2910. First published on Mar 7 2005; 10.1200/JCO.2005.03.163. [Abstract] [Full Text] [PDF]
	The Combined Percentage of Gleason Patterns 4 and 5 Is the Best Predictor of Cancer Progression After Radical Prostatectomy
	Liang Cheng, Michael O. Koch, Beth E. Juliar, Joanne K. Daggy, Richard S. Foster, Richard Bihrle, and Thomas A. Gardner
	JCO May 1 2005: 2911–2917. [Abstract] [Full Text] [PDF]
	Natural History of Rising Serum Prostate-Specific Antigen in Men With Castrate Nonmetastatic Prostate Cancer
	Matthew R. Smith, Fairooz Kabbinavar, Fred Saad, Arif Hussain, Marc C. Gittelman, David L. Bilhartz, Chris Wynne, Robin Murray, Norman R. Zinner, Claude Schulman, Ronald Linnartz, Ming Zheng, Carsten Goessl, Yong-Jiang Hei, Eric J. Small, Richard Cook, and Celestia S. Higano
	JCO May 1 2005: 2918–2925. [Abstract] [Full Text] [PDF]

Lung Cancer
	Platinum-Based Versus Non-Platinum-Based Chemotherapy in Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis of the Published Literature
	Giannicola D'Addario, Melania Pintilie, Natasha B. Leighl, Ronald Feld, Thomas Cerny, and Frances A. Shepherd
	JCO May 1 2005: 2926–2936. First published on Feb 22 2005; 10.1200/JCO.2005.03.045. [Abstract] [Full Text] [PDF]
	Vinorelbine Plus Cisplatin Versus Docetaxel Plus Gemcitabine in Advanced Non-Small-Cell Lung Cancer: A Phase III Randomized Trial
	Vassilis Georgoulias, Alexandros Ardavanis, Xanthi Tsiafaki, Athina Agelidou, Penelope Mixalopoulou, Ourania Anagnostopoulou, Panagiotis Ziotopoulos, Michael Toubis, Kostas Syrigos, Nikolaos Samaras, Aris Polyzos, Anna Christou, Stylianos Kakolyris, Charalambos Kouroussis, Nikolaos Androulakis, George Samonis, and Dora Chatzidaki
	JCO May 1 2005: 2937–2945. First published on Feb 22 2005; 10.1200/JCO.2005.04.016. [Abstract] [Full Text] [PDF]
	Clinically Meaningful Improvement in Symptoms and Quality of Life for Patients With Non-Small-Cell Lung Cancer Receiving Gefitinib in a Randomized Controlled Trial
	David Cella, Roy S. Herbst, Thomas J. Lynch, Diane Prager, Chandra P. Belani, Joan H. Schiller, Anne Heyes, Judith S. Ochs, Michael K. Wolf, Andrea C. Kay, Mark G. Kris, and Ronald B. Natale
	JCO May 1 2005: 2946–2954. First published on Feb 7 2005; 10.1200/JCO.2005.05.153. [Abstract] [Full Text] [PDF]
	Time From Treatment to Subsequent Diagnosis of Brain Metastases in Stage III Non–Small-Cell Lung Cancer: A Retrospective Review by the Southwest Oncology Group
	Laurie E. Gaspar, Kari Chansky, Kathy S. Albain, Eric Vallieres, Valerie Rusch, John J. Crowley, Robert B. Livingston, and David R. Gandara
	JCO May 1 2005: 2955–2961. [Abstract] [Full Text] [PDF]
	Results of the Dutch National Study of the Palliative Effect of Irradiation Using Two Different Treatment Schemes for Non–Small-Cell Lung Cancer
	Gijsbert W.P.M. Kramer, Stofferinus L. Wanders, Ed M. Noordijk, Ernest J.A. Vonk, Hans C. van Houwelingen, Wilbert B. van den Hout, Ronald B. Geskus, Mirjam Scholten, and Jan-Willem H. Leer
	JCO May 1 2005: 2962–2970. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Eradication of Minimal Residual Disease in B-Cell Chronic Lymphocytic Leukemia After Alemtuzumab Therapy Is Associated With Prolonged Survival
	Paul Moreton, Ben Kennedy, Guy Lucas, Michael Leach, Saad M.B. Rassam, Andrew Haynes, Jane Tighe, David Oscier, Christopher Fegan, Andy Rawstron, and Peter Hillmen
	JCO May 1 2005: 2971–2979. First published on Feb 28 2005; 10.1200/JCO.2005.04.021. [Abstract] [Full Text] [PDF]

Breast Cancer
	Neoadjuvant Percutaneous 4-Hydroxytamoxifen Decreases Breast Tumoral Cell Proliferation: A Prospective Controlled Randomized Study Comparing Three Doses of 4-Hydroxytamoxifen Gel to Oral Tamoxifen
	Philippe Rouanet, Gustavo Linares-Cruz, François Dravet, Sylvain Poujol, Sophie Gourgou, Joelle Simony-Lafontaine, Jean Grenier, Andrew Kramar, Jean Girault, Elisabeth Le Nestour, and Thierry Maudelonde
	JCO May 1 2005: 2980–2987. [Abstract] [Full Text] [PDF]
	Phase III Randomized Trial of Doxorubicin and Docetaxel Versus Doxorubicin and Cyclophosphamide As Primary Medical Therapy in Women With Breast Cancer: An Anglo-Celtic Cooperative Oncology Group Study
	T.R. Jeffry Evans, Ann Yellowlees, Elizabeth Foster, Helena Earl, David A. Cameron, Andrew W. Hutcheon, Robert E. Coleman, Timothy Perren, Christopher J. Gallagher, Mary Quigley, John Crown, Alison L. Jones, Martin Highley, Robert C.F. Leonard, and Janine L. Mansi
	JCO May 1 2005: 2988–2995. [Abstract] [Full Text] [PDF]
	Mitotic Index and Benefit of Adjuvant Anthracycline-Based Chemotherapy in Patients With Early Breast Cancer
	Fabrice Andre, Ahmed Khalil, Khemaies Slimane, Christophe Massard, Marie Christine Mathieu, Stéphane Vignot, Hazem Assi, Suzette Delaloge, and Marc Spielmann
	JCO May 1 2005: 2996–3000. [Abstract] [Full Text] [PDF]
	Patterns and Correlates of Local Therapy for Women With Ductal Carcinoma-In-Situ
	Steven J. Katz, Paula M. Lantz, Nancy K. Janz, Angela Fagerlin, Kendra Schwartz, Lihua Liu, Dennis Deapen, Barbara Salem, Indu Lakhani, and Monica Morrow
	JCO May 1 2005: 3001–3007. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Concomitant Boost Radiation Plus Concurrent Cisplatin for Advanced Head and Neck Carcinomas: Radiation Therapy Oncology Group Phase II Trial 99-14
	K. Kian Ang, Jonathan Harris, Adam S. Garden, Andy Trotti, Christopher U. Jones, Luis Carrascosa, Jonathan D. Cheng, Sharon S. Spencer, Arlene Forastiere, and Randal S. Weber
	JCO May 1 2005: 3008–3015. [Abstract] [Full Text] [PDF]
	Xerostomia Following Radiotherapy of the Head and Neck Affects Vocal Function
	Jong-Lyel Roh, Ah-Young Kim, and Moon June Cho
	JCO May 1 2005: 3016–3023. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Central Venous Lines in Children With Lesser Risk Acute Lymphoblastic Leukemia: Optimal Type and Timing of Placement
	Thomas W. McLean, Christen J. Fisher, Beverly M. Snively, and Allen R. Chauvenet
	JCO May 1 2005: 3024–3029. [Abstract] [Full Text] [PDF]
	Increased Fluorine-18 2-Fluoro-2-Deoxy-D-Glucose (FDG) Uptake in Childhood CNS Tumors Is Correlated With Malignancy Grade: A Study With FDG Positron Emission Tomography/Magnetic Resonance Imaging Coregistration and Image Fusion
	Lise Borgwardt, Liselotte Højgaard, Henrik Carstensen, Henning Laursen, Markus Nowak, Carsten Thomsen, and Kjeld Schmiegelow
	JCO May 1 2005: 3030–3037. [Abstract] [Full Text] [PDF]
	Expression of Interleukin-10 Splicing Variants Is a Positive Prognostic Feature in Relapsed Childhood Acute Lymphoblastic Leukemia
	Shuling Wu, Reinhard Geßner, Tillmann Taube, Arend von Stackelberg, Günter Henze, and Karl Seeger
	JCO May 1 2005: 3038–3042. [Abstract] [Full Text] [PDF]

Melanoma
	Role of the CDKN2A Locus in Patients With Multiple Primary Melanomas
	Susana Puig, Josep Malvehy, Cèlia Badenas, Anna Ruiz, Dolores Jimenez, Francisco Cuellar, Antoni Azon, Urbá Gonzàlez, Teresa Castel, Antoni Campoy, Josep Herrero, Rosa Martí, Joan Brunet-Vidal, and Montserrat Milà
	JCO May 1 2005: 3043–3051. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Depression, Correlates of Depression, and Receipt of Depression Care Among Low-Income Women With Breast or Gynecologic Cancer
	Kathleen Ell, Kathleen Sanchez, Betsy Vourlekis, Pey-Jiuan Lee, Megan Dwight-Johnson, Isabel Lagomasino, Laila Muderspach, and Christy Russell
	JCO May 1 2005: 3052–3060. [Abstract] [Full Text] [PDF]
	Side Effects and Cancer-Related Stress Determine Quality of Life in Long-Term Survivors of Testicular Cancer
	Arnstein Mykletun, Alv A. Dahl, Carl Fredrik Haaland, Roy Bremnes, Olav Dahl, Olbjørn Klepp, Erik Wist, and Sophie D. Fosså
	JCO May 1 2005: 3061–3068. [Abstract] [Full Text] [PDF]

Sarcomas
	Evaluation of Epothilone B Analog in Advanced Soft Tissue Sarcoma: A Phase II Study of the Phase II Consortium
	Scott Okuno, William J. Maples, Michelle R. Mahoney, Tom Fitch, James Stewart, Paula M. Fracasso, Michael Kraut, David S. Ettinger, Fitzroy Dawkins, and Charles Erlichman
	JCO May 1 2005: 3069–3073. [Abstract] [Full Text] [PDF]

Tumor Biology
	TGFBR16A May Contribute to Hereditary Colorectal Cancer
	Yansong Bian, Trinidad Caldes, Juul Wijnen, Patrick Franken, Hans Vasen, Virginia Kaklamani, Khédoudja Nafa, Paolo Peterlongo, Nathan Ellis, John A. Baron, John Burn, Gabriela Moeslein, Patrick J. Morrison, Yu Chen, Habibul Ahsan, Patrice Watson, Henry T. Lynch, Albert de la Chapelle, Riccardo Fodde, and Boris Pasche
	JCO May 1 2005: 3074–3078. [Abstract] [Full Text] [PDF]

Radiation Oncology
	Randomized Trial of Hyperthermia and Radiation for Superficial Tumors
	Ellen L. Jones, James R. Oleson, Leonard R. Prosnitz, Thaddeus V. Samulski, Zeljko Vujaskovic, Daohai Yu, Linda L. Sanders, and Mark W. Dewhirst
	JCO May 1 2005: 3079–3085. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Catalytic Subunit of Human Telomerase Reverse Transcriptase Is an Independent Predictor of Survival in Patients Undergoing Curative Resection of Hepatic Colorectal Metastases: A Multicenter Analysis
	Julien Dômont, Timothy M. Pawlik, Valérie Boige, Mathieu Rose, Jean-Christophe Weber, Paulo M. Hoff, Thomas D. Brown, Daria Zorzi, Luc Morat, Jean-Pierre Pignon, Asif Rashid, Daniel Jaeck, Laure Sabatier, Dominique Elias, Thomas Tursz, Jean-Charles Soria, and Jean-Nicolas Vauthey
	JCO May 1 2005: 3086–3093. [Abstract] [Full Text] [PDF]
	Clinicopathologic Behavior of Gastric Adenocarcinoma in Hispanic Patients: Analysis of a Single Institution's Experience Over 15 Years
	James C. Yao, Jennifer F. Tseng, Samidha Worah, Kenneth R. Hess, Paul F. Mansfield, Christopher H. Crane, Isac I. Schnirer, Satish Reddy, Silvia S. Chiang, Azmeena Najam, Christina Yu, Geoffrey G. Giacco, Keping Xie, Tsung-Teh Wu, Barry W. Feig, Peter W.T. Pisters, and Jaffer A. Ajani
	JCO May 1 2005: 3094–3103. [Abstract] [Full Text] [PDF]
	Capecitabine As First-Line Treatment for Patients Older Than 70 Years With Metastatic Colorectal Cancer: An Oncopaz Cooperative Group Study
	Jaime Feliu, Pilar Escudero, Ferrán Llosa, Matilde Bolaños, Jose-Manuel Vicent, Alfonso Yubero, Jose-Javier Sanz-Lacalle, Rafael Lopez, Luis Lopez-Gómez, Enrique Casado, María-José Gómez-Reina, and Manuel González-Baron
	JCO May 1 2005: 3104–3111. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Systematic Review of Barriers to the Recruitment of Older Patients With Cancer Onto Clinical Trials
	Carol A. Townsley, Rita Selby, and Lillian L. Siu
	JCO May 1 2005: 3112–3124. [Abstract] [Full Text] [PDF]

SPECIAL ARTICLE
	Treatment of Advanced Non–Small-Cell Lung Cancer in the Elderly: Results of an International Expert Panel
	Cesare Gridelli, Matti Aapro, Andrea Ardizzoni, Lodovico Balducci, Filippo De Marinis, Karen Kelly, Thierry Le Chevalier, Christian Manegold, Francesco Perrone, Rafael Rosell, Frances Shepherd, Luigi De Petris, Massimo Di Maio, and Corey Langer
	JCO May 1 2005: 3125–3137. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Plasma Cell Problems: CASE 1. Disseminated Cutaneous Plasmacytomas Treated With Total Skin Electron Radiotherapy

Scott R. Floyd, Liron Pantanowitz, David F. McDermott, Jennifer Yannucci, Jane A. Driver, Mary Ann Stevenson, Benjamin D. Smith, Lynn D. Wilson, and Paul G. Richardson

JCO May 1 2005: 3138–3140. [Full Text] [PDF]

Plasma Cell Problems: CASE 2. Extramedullary Cardiac Plasmacytoma Presenting With Cardiac Tamponade

C.S. Chim, F. Loong, E.S.K. Ma, W. Cheung, R.H.W. Chan, and G.C. Ooi

JCO May 1 2005: 3140–3143. [Full Text] [PDF]

Plasma Cell Problems: CASE 3. Plasmacytoma Mimicking a Paraganglioma of the Skull Base: Diagnostic Value of Somatostatin Receptor Scintigraphy

Michèle Duet, Patrice Tran Ba Huy, Michel Wassef, and Frédéric Liote

JCO May 1 2005: 3143–3145. [Full Text] [PDF]

ART OF ONCOLOGY

Necessary Collusion: Prognostic Communication With Advanced Cancer Patients

Paul R. Helft

JCO May 1 2005: 3146–3150. [Full Text] [PDF]

A Strategy for Hope: A Commentary on Necessary Collusion

Jerome E. Groopman

JCO May 1 2005: 3151–3152. [Full Text] [PDF]

Is Collusion Necessary? A Commentary on Necessary Collusion

Gregory P. Kalemkerian

JCO May 1 2005: 3153–3154. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

Treatment of Brain Metastases From Melanoma

Sewa S. Legha

JCO May 1 2005: 3155. [Full Text] [PDF]

In Reply:

Sanjiv S. Agarwala

JCO May 1 2005: 3155-a–3156. [Full Text] [PDF]

Treatment of Wilms Tumor: An International Perspective

Jan de Kraker and Kathy Pritchard Jones

JCO May 1 2005: 3156–3157. [Full Text] [PDF]

In Reply:

Daniel Green

JCO May 1 2005: 3157–3158. [Full Text] [PDF]

p53 Expression As a Prognostic Indicator in Hodgkin's Lymphoma

Nelson Spector, Cristiane B. Milito, Irene Biasoli, and José Carlos Morais

JCO May 1 2005: 3158–3159. [Full Text] [PDF]

In Reply:

Juan F. Garcia

JCO May 1 2005: 3159–3160. [Full Text] [PDF]

Mammaglobin Remains a Useful Marker for the Detection of Breast Cancer Cells in Peripheral Blood

Otto Zach and Dieter Lutz

JCO May 1 2005: 3160. [Full Text] [PDF]

In Reply:

P.N. Span, C.G.J. Sweep, L.V.A.M. Beex, and J.A. Foekens

JCO May 1 2005: 3160-a–3161. [Full Text] [PDF]

Chemoradiotherapy for Localized Non-Hodgkin's Lymphoma: Lessons From Old Studies

Gul Basaran, Mert Basaran, and Haluk Onat

JCO May 1 2005: 3161–3162. [Full Text] [PDF]

In Reply:

Sandra J. Horning

JCO May 1 2005: 3162–3163. [Full Text] [PDF]

Reproducibility of a Semiquantitative Measurement of Circulating DNA in Plasma From Neoplastic Patients

Milo Frattini, Debora Balestra, Paolo Verderio, Gianfrancesco Gallino, Ermanno Leo, Gabriella Sozzi, Marco A. Pierotti, and Maria Grazia Daidone

JCO May 1 2005: 3163–3164. [Full Text] [PDF]

In Reply:

Gabriella Sozzi, Davide Conte, and Luca Roz

JCO May 1 2005: 3164–3165. [Full Text] [PDF]

Genetic Cancer Risk Assessment in the Newly Diagnosed Breast Cancer Patient Is Useful and Possible in Practice

Melanie R. Palomares, Benjamin Paz, and Jeffrey N. Weitzel

JCO May 1 2005: 3165–3166. [Full Text] [PDF]

In Reply:

Beth N. Peshkin, Claudine Isaacs, Shawna Willey, and Marc D. Schwartz

JCO May 1 2005: 3166–3167. [Full Text] [PDF]

No Evidence for Correlation of DDX1 Gene Amplification With Improved Survival Probability in Patients With MYCN-Amplified Neuroblastomas

Katleen De Preter, Frank Speleman, Valérie Combaret, John Lunec, Julian Board, Andy Pearson, Anne De Paepe, Nadine Van Roy, Geneviève Laureys, and Jo Vandesompele

JCO May 1 2005: 3167–3168. [Full Text] [PDF]

In Reply:

Axel Weber, Patricia Imisch, Eckhard Bergmann, and Holger Christiansen

JCO May 1 2005: 3168–3170. [Full Text] [PDF]

Use of Radiolabeled Bombesin in Humans

Francesco Scopinaro, Giuseppe De Vincentis, and Alexandra D. Varvarigou

JCO May 1 2005: 3170–3171. [Full Text] [PDF]

In Reply:

Bieke Van Den Bossche and Christophe Van de Wiele

JCO May 1 2005: 3171. [Full Text] [PDF]

Safety of Exemestane in the Intergroup Exemestane Study

R. Charles Coombes, Judith M. Bliss, and Emma Hall

JCO May 1 2005: 3171-a–3172. [Full Text] [PDF]

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