Other Issues:		[Index by Author]
Contents:	Volume 27, Issue 34 December 1, 2009

	EDITORIALS
	COMMENTS AND CONTROVERSIES
	ORIGINAL REPORTS
	Breast Cancer
	Hematologic Malignancies
	Gastrointestinal Cancer
	Neurooncology
	Head and Neck Cancer
	Palliative and Supportive Care
	Melanoma
	Pediatric Oncology
	Genitourinary Cancer
	Phase I and Clinical Pharmacology
	Thoracic Oncology
	Health Services and Outcomes
	REVIEW ARTICLE
	BIOLOGY OF NEOPLASIA
	ART OF ONCOLOGY
	CORRECTION
	DIAGNOSIS IN ONCOLOGY
	CORRESPONDENCE

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                                      EDITORIALS

Refining Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: T Stands for Trastuzumab, Tumor Size, and Treatment Strategy Harold J. Burstein and Eric P. Winer JCO Dec 2009: 5671–5673. First published on Nov 2 2009; 10.1200/JCO.2009.24.2222. [Full Text] [PDF]

Predicting the Risk of Axillary Nodal Metastases and Their Use in Selecting Breast Surgery Options Lisa K. Jacobs, Charles M. Balch, and Seng-jaw Soong JCO Dec 2009: 5673–5675. First published on Oct 13 2009; 10.1200/JCO.2009.24.4525. [Full Text] [PDF]

Relapse/Refractory Myeloma Patient: Potential Treatment Guidelines Jesús F. San Miguel JCO Dec 2009: 5676–5677. First published on Sep 28 2009; 10.1200/JCO.2009.24.3683. [Full Text] [PDF]

Stop and Go: Yes or No? Howard S. Hochster JCO Dec 2009: 5677–5679. First published on Sep 28 2009; 10.1200/JCO.2009.24.5209. [Full Text] [PDF]

                                      COMMENTS AND CONTROVERSIES

Bladder Cancer: Narrowing the Gap Between Evidence and Practice Maha H.A. Hussain, David P. Wood, Dean F. Bajorin, Bernard H. Bochner, Robert Dreicer, Donald L. Lamm, Michael A. O'Donnell, Arlene O. Siefker-Radtke, Dan Theodorescu, and Colin P. Dinney JCO Dec 2009: 5680–5684. First published on Oct 26 2009; 10.1200/JCO.2009.23.6901. [Full Text] [PDF]

                                      ORIGINAL REPORTS
Breast Cancer

Fluorouracil, Epirubicin, and Cyclophosphamide With Either Docetaxel or Vinorelbine, With or Without Trastuzumab, As Adjuvant Treatments of Breast Cancer: Final Results of the FinHer Trial Heikki Joensuu, Petri Bono, Vesa Kataja, Tuomo Alanko, Riitta Kokko, Raija Asola, Tapio Utriainen, Taina Turpeenniemi-Hujanen, Sirkku Jyrkkiö, Kari Möykkynen, Leena Helle, Seija Ingalsuo, Marjo Pajunen, Mauri Huusko, Tapio Salminen, Päivi Auvinen, Hannu Leinonen, Mika Leinonen, Jorma Isola, and Pirkko-Liisa Kellokumpu-Lehtinen JCO Dec 2009: 5685–5692. First published on Nov 2 2009; 10.1200/JCO.2008.21.4577. [Abstract] [Full Text] [PDF]

Clinical Relevance of HER2 Overexpression/Amplification in Patients With Small Tumor Size and Node-Negative Breast Cancer Giuseppe Curigliano, Giuseppe Viale, Vincenzo Bagnardi, Luca Fumagalli, Marzia Locatelli, Nicole Rotmensz, Raffaella Ghisini, Marco Colleoni, Elisabetta Munzone, Paolo Veronesi, Stefano Zurrida, Franco Nolè, and Aron Goldhirsch JCO Dec 2009: 5693–5699. First published on Nov 2 2009; 10.1200/JCO.2009.22.0962. [Abstract] [Full Text] [PDF]

High Risk of Recurrence for Patients With Breast Cancer Who Have Human Epidermal Growth Factor Receptor 2–Positive, Node-Negative Tumors 1 cm or Smaller Ana M. Gonzalez-Angulo, Jennifer K. Litton, Kristine R. Broglio, Funda Meric-Bernstam, Ronjay Rakkhit, Fatima Cardoso, Florentia Peintinger, Emer O. Hanrahan, Aysegul Sahin, Merih Guray, Denis Larsimont, Francesco Feoli, Heidi Stranzl, Thomas A. Buchholz, Vicente Valero, Richard Theriault, Martine Piccart-Gebhart, Peter M. Ravdin, Donald A. Berry, and Gabriel N. Hortobagyi JCO Dec 2009: 5700–5706. First published on Nov 2 2009; 10.1200/JCO.2009.23.2025. [Abstract] [Full Text] [PDF]

Prospective Multicenter Comparison of Models to Predict Four or More Involved Axillary Lymph Nodes in Patients With Breast Cancer With One to Three Metastatic Sentinel Lymph Nodes Gabrielle Werkoff, Eric Lambaudie, Eric Fondrinier, Jean Levêque, Fréderic Marchal, Michele Uzan, Emmanuel Barranger, François Guillemin, Emile Darai, Serge Uzan, Gilles Houvenaeghel, Roman Rouzier, and Charles Coutant JCO Dec 2009: 5707–5712. First published on Oct 13 2009; 10.1200/JCO.2009.21.9139. [Abstract] [Full Text] [PDF]

Hematologic Malignancies

Multicenter, Phase I, Dose-Escalation Trial of Lenalidomide Plus Bortezomib for Relapsed and Relapsed/Refractory Multiple Myeloma Paul G. Richardson, Edie Weller, Sundar Jagannath, David E. Avigan, Melissa Alsina, Robert L. Schlossman, Amitabha Mazumder, Nikhil C. Munshi, Irene M. Ghobrial, Deborah Doss, Diane L. Warren, Laura E. Lunde, Mary McKenney, Carol Delaney, Constantine S. Mitsiades, Teru Hideshima, William Dalton, Robert Knight, Dixie-Lee Esseltine, and Kenneth C. Anderson JCO Dec 2009: 5713–5719. First published on Sep 28 2009; 10.1200/JCO.2009.22.2679. [Abstract] [Full Text] [PDF] [Publisher's Note]

Achievement of at Least Very Good Partial Response Is a Simple and Robust Prognostic Factor in Patients With Multiple Myeloma Treated With High-Dose Therapy: Long-Term Analysis of the IFM 99-02 and 99-04 Trials Jean-Luc Harousseau, Herve Avet-Loiseau, Michel Attal, Catherine Charbonnel, Frederic Garban, Cyrille Hulin, Mauricette Michallet, Thierry Facon, Laurent Garderet, Gerald Marit, Nicolas Ketterer, Thierry Lamy, Laurent Voillat, Francois Guilhot, Chantal Doyen, Claire Mathiot, and Philippe Moreau JCO Dec 2009: 5720–5726. First published on Oct 13 2009; 10.1200/JCO.2008.21.1060. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer

Can Chemotherapy Be Discontinued in Unresectable Metastatic Colorectal Cancer? The GERCOR OPTIMOX2 Study Benoist Chibaudel, Frédérique Maindrault-Goebel, Gérard Lledo, Laurent Mineur, Thierry André, Mostepha Bennamoun, May Mabro, Pascal Artru, Elisabeth Carola, Michel Flesch, Olivier Dupuis, Philippe Colin, Annette K. Larsen, Pauline Afchain, Christophe Tournigand, Christophe Louvet, and Aimery de Gramont JCO Dec 2009: 5727–5733. First published on Sep 28 2009; 10.1200/JCO.2009.23.4344. [Abstract] [Full Text] [PDF]

Alpha-Fetoprotein Response After Locoregional Therapy for Hepatocellular Carcinoma: Oncologic Marker of Radiologic Response, Progression, and Survival Ahsun Riaz, Robert K. Ryu, Laura M. Kulik, Mary F. Mulcahy, Robert J. Lewandowski, Jeet Minocha, Saad M. Ibrahim, Kent T. Sato, Talia Baker, Frank H. Miller, Steven Newman, Reed Omary, Michael Abecassis, Al B. Benson, III, and Riad Salem JCO Dec 2009: 5734–5742. First published on Oct 5 2009; 10.1200/JCO.2009.23.1282. [Abstract] [Full Text] [PDF]

Neurooncology

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network Michael Weller, Jörg Felsberg, Christian Hartmann, Hilmar Berger, Joachim P. Steinbach, Johannes Schramm, Manfred Westphal, Gabriele Schackert, Matthias Simon, Jörg C. Tonn, Oliver Heese, Dietmar Krex, Guido Nikkhah, Torsten Pietsch, Otmar Wiestler, Guido Reifenberger, Andreas von Deimling, and Markus Loeffler JCO Dec 2009: 5743–5750. First published on Oct 5 2009; 10.1200/JCO.2009.23.0805. [Abstract] [Full Text] [PDF]

Head and Neck Cancer

Effect of Epoetin Alfa on Survival and Cancer Treatment–Related Anemia and Fatigue in Patients Receiving Radical Radiotherapy With Curative Intent for Head and Neck Cancer Peter J. Hoskin, Martin Robinson, Nicholas Slevin, David Morgan, Kevin Harrington, and Christopher Gaffney JCO Dec 2009: 5751–5756. First published on Nov 2 2009; 10.1200/JCO.2009.22.3693. [Abstract] [Full Text] [PDF]

Palliative and Supportive Care

Prognostic Acceptance and the Well-Being of Patients Receiving Palliative Care for Cancer Genevieve N. Thompson, Harvey M. Chochinov, Keith G. Wilson, Christine J. McPherson, Srini Chary, Fiona M. O'Shea, David R. Kuhl, Robin L. Fainsinger, Pierre R. Gagnon, and Karen A. Macmillan JCO Dec 2009: 5757–5762. First published on Oct 13 2009; 10.1200/JCO.2009.22.9799. [Abstract] [Full Text] [PDF]

Melanoma

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma Neil N. Senzer, Howard L. Kaufman, Thomas Amatruda, Mike Nemunaitis, Tony Reid, Gregory Daniels, Rene Gonzalez, John Glaspy, Eric Whitman, Kevin Harrington, Howard Goldsweig, Tracey Marshall, Colin Love, Robert Coffin, and John J. Nemunaitis JCO Dec 2009: 5763–5771. First published on Nov 2 2009; 10.1200/JCO.2009.24.3675. [Abstract] [Full Text] [PDF]

Melanoma Prognostic Model Using Tissue Microarrays and Genetic Algorithms Bonnie E. Gould Rothberg, Aaron J. Berger, Annette M. Molinaro, Antonio Subtil, Michael O. Krauthammer, Robert L. Camp, William R. Bradley, Stephan Ariyan, Harriet M. Kluger, and David L. Rimm JCO Dec 2009: 5772–5780. First published on Nov 2 2009; 10.1200/JCO.2009.22.8239. [Abstract] [Full Text] [PDF]

Pediatric Oncology

Survival After Second Primary Neoplasms of the Brain or Spinal Cord in Survivors of Childhood Cancer: Results From the British Childhood Cancer Survivor Study Aliki J. Taylor, Clare Frobisher, David W. Ellison, Raoul C. Reulen, David L. Winter, Roger E. Taylor, Charles A. Stiller, Emma R. Lancashire, Edward C.G. Tudor, Christina Baggott, Shaun May, and Mike M. Hawkins JCO Dec 2009: 5781–5787. First published on Sep 28 2009; 10.1200/JCO.2009.22.4386. [Abstract] [Full Text] [PDF]

Genitourinary Cancer

Phase II Study of Erlotinib in Patients With Locally Advanced or Metastatic Papillary Histology Renal Cell Cancer: SWOG S0317 Michael S. Gordon, Michael Hussey, Raymond B. Nagle, Primo N. Lara, Jr, Philip C. Mack, Janice Dutcher, Wolfram Samlowski, Joseph I. Clark, David I. Quinn, Chong-Xian Pan, and David Crawford JCO Dec 2009: 5788–5793. First published on Nov 2 2009; 10.1200/JCO.2008.18.8821. [Abstract] [Full Text] [PDF]

Prognostic Factors for Overall Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Vascular Endothelial Growth Factor–Targeted Agents: Results From a Large, Multicenter Study Daniel Y.C. Heng, Wanling Xie, Meredith M. Regan, Mark A. Warren, Ali Reza Golshayan, Chakshu Sahi, Bernhard J. Eigl, J. Dean Ruether, Tina Cheng, Scott North, Peter Venner, Jennifer J. Knox, Kim N. Chi, Christian Kollmannsberger, David F. McDermott, William K. Oh, Michael B. Atkins, Ronald M. Bukowski, Brian I. Rini, and Toni K. Choueiri JCO Dec 2009: 5794–5799. First published on Oct 13 2009; 10.1200/JCO.2008.21.4809. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1 Anthony W. Tolcher, John Sarantopoulos, Amita Patnaik, Kyriakos Papadopoulos, Chia-Chi Lin, Jordi Rodon, Barbara Murphy, Bruce Roth, Ian McCaffery, Kevin S. Gorski, Brianne Kaiser, Min Zhu, Hongjie Deng, Greg Friberg, and Igor Puzanov JCO Dec 2009: 5800–5807. First published on Sep 28 2009; 10.1200/JCO.2009.23.6745. [Abstract] [Full Text] [PDF]

Thoracic Oncology

Randomized Phase III Trial of Gemcitabine-Based Chemotherapy With In Situ RRM1 and ERCC1 Protein Levels for Response Prediction in Non–Small-Cell Lung Cancer Craig Reynolds, Coleman Obasaju, Michael J. Schell, Xueli Li, Zhong Zheng, David Boulware, John R. Caton, Linda C. DeMarco, Mark A. O'Rourke, Gail Shaw Wright, Kristi A. Boehm, Lina Asmar, Jane Bromund, Guangbin Peng, Matthew J. Monberg, and Gerold Bepler JCO Dec 2009: 5808–5815. First published on Nov 2 2009; 10.1200/JCO.2009.21.9766. [Abstract] [Full Text] [PDF]

Quality of Life Supersedes the Classic Prognosticators for Long-Term Survival in Locally Advanced Non–Small-Cell Lung Cancer: An Analysis of RTOG 9801 Benjamin Movsas, Jennifer Moughan, Linda Sarna, Corey Langer, Maria Werner-Wasik, Nicos Nicolaou, Ritsuko Komaki, Mitchell Machtay, Todd Wasserman, and Deborah Watkins Bruner JCO Dec 2009: 5816–5822. First published on Oct 26 2009; 10.1200/JCO.2009.23.7420. [Abstract] [Full Text] [PDF]

Polymorphisms in the CASPASE Genes and Survival in Patients With Early-Stage Non–Small-Cell Lung Cancer Seung Soo Yoo, Jin Eun Choi, Won-Kee Lee, Yi-Young Choi, Sin Kam, Min Jung Kim, Hyo-Sung Jeon, Eung-Bae Lee, Dong Sun Kim, Myung-Hoon Lee, In-San Kim, Sanghoon Jheon, and Jae Yong Park JCO Dec 2009: 5823–5829. First published on Oct 13 2009; 10.1200/JCO.2009.23.1738. [Abstract] [Full Text] [PDF]

Health Services and Outcomes

To Tell or Not to Tell: The Community Wants to Know About Expensive Anticancer Drugs As a Potential Treatment Option Linda Mileshkin, Penelope E. Schofield, Michael Jefford, Emilia Agalianos, Michele Levine, Alan Herschtal, Julian Savulescu, Jacqui Ann Thomson, and John R. Zalcberg JCO Dec 2009: 5830–5837. First published on Sep 28 2009; 10.1200/JCO.2009.22.7793. [Abstract] [Full Text] [PDF] [Data Supplement]

                                      REVIEW ARTICLE

Understanding the Mechanisms Behind Trastuzumab Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Neil L. Spector and Kimberly L. Blackwell JCO Dec 2009: 5838–5847. First published on Nov 2 2009; 10.1200/JCO.2009.22.1507. [Abstract] [Full Text] [PDF]

                                      BIOLOGY OF NEOPLASIA

MicroRNAs in Cancer: Small Molecules With a Huge Impact Marilena V. Iorio and Carlo M. Croce JCO Dec 2009: 5848–5856. First published on Nov 2 2009; 10.1200/JCO.2009.24.0317. [Abstract] [Full Text] [PDF]

                                      ART OF ONCOLOGY

The Homecoming Navneet S. Majhail JCO Dec 2009: 5857–5858. First published on Aug 24 2009; 10.1200/JCO.2009.24.4681. [Full Text] [PDF]

                                      CORRECTION

Author Correction JCO Dec 2009: 5859. [Full Text] [PDF]

Author Correction JCO Dec 2009: 5859. [Full Text] [PDF]

Author Correction JCO Dec 2009: 5859. [Full Text] [PDF]

Journal Correction JCO Dec 2009: 5859. [Full Text] [PDF]

                                      DIAGNOSIS IN ONCOLOGY

Rapid Clinical Deterioration and Leukemoid Reaction After Treatment of Urothelial Carcinoma of the Bladder: Possible Effect of Granulocyte Colony-Stimulating Factor Francisco A. Perez, Corinne L. Fligner, and Evan Y. Yu JCO Dec 2009: e215–e217. First published on Sep 28 2009; 10.1200/JCO.2009.22.4931. [Full Text] [PDF]

Geographic Distribution of Lapatinib-Induced Skin Rash: Sparing of Abdominal Skin Persists in the Transverse Rectus Abdominis Myocutaneous Flap Nancy U. Lin, Elizabeth Kasparian, Daniel E. Morganstern, and Clair Beard JCO Dec 2009: e218–e219. First published on Sep 28 2009; 10.1200/JCO.2009.22.7868. [Full Text] [PDF]

                                      CORRESPONDENCE

Bone Marrow Fibrosis and Diagnosis of Essential Thrombocythemia Juergen Thiele, Hans Michael Kvasnicka, James W. Vardiman, Attilio Orazi, Vito Franco, Heinz Gisslinger, Gunnar Birgegard, Martin Griesshammer, and Ayalew Tefferi JCO Dec 2009: e220–e221. First published on Oct 26 2009; 10.1200/JCO.2009.24.3485. [Full Text] [PDF]

Reply to J. Thiele et al Peter J. Campbell, David Bareford, Wendy N. Erber, Bridget S. Wilkins, Penny A. Wright, Georgina Buck, Keith Wheatley, Claire N. Harrison, and Anthony R. Green JCO Dec 2009: e222–e223. First published on Oct 26 2009; 10.1200/JCO.2009.24.5233. [Full Text] [PDF]

Molecular Screening for Lynch Syndrome: From Bench to Bedside Lars Henrik Jensen, Jan Lindebjerg, Steen Kølvraa, and Dorthe G. Crüger JCO Dec 2009: e224. First published on Oct 26 2009; 10.1200/JCO.2009.24.6744. [Full Text] [PDF]

Reply to L.H. Jensen et al and S. Jahn et al Heather Hampel, Wendy Frankel, and Albert de la Chapelle JCO Dec 2009: e225. First published on Oct 26 2009; 10.1200/JCO.2009.24.7015. [Full Text] [PDF]

LKB1 and Mammalian Target of Rapamycin As Predictive Factors for the Anticancer Efficacy of Metformin Regan M. Memmott and Phillip A. Dennis JCO Dec 2009: e226. First published on Oct 26 2009; 10.1200/JCO.2009.25.3963. [Full Text] [PDF]

Reply to R.M. Memmott et al Pamela J. Goodwin, Jennifer A. Ligibel, and Vuk Stambolic JCO Dec 2009: e227. First published on Oct 26 2009; 10.1200/JCO.2009.25.4284. [Full Text] [PDF]

Androgen Deprivation Therapy and Prostate Cancer Duration Scott G. Williams, Tom Pickles, and Mark K. Buyyounouski JCO Dec 2009: e228. First published on Nov 2 2009; 10.1200/JCO.2009.24.4137. [Full Text] [PDF]

Reply to S.G. Williams et al Luis Souhami, Kyounghwa Bae, and Howard Sandler JCO Dec 2009: e229. First published on Nov 2 2009; 10.1200/JCO.2009.24.5217. [Full Text] [PDF]

Recognizing Paraneoplastic Limbic Encephalitis Josep Dalmau JCO Dec 2009: e230–e231. First published on Nov 2 2009; 10.1200/JCO.2009.24.4822. [Full Text] [PDF]

Reply to J. Dalmau Sebastian Rauer and Hendrik Veelken JCO Dec 2009: e232. First published on Nov 2 2009; 10.1200/JCO.2009.24.6009. [Full Text] [PDF]

False-Positive MIBG Scans With Normal Computed Tomography Imaging in Patients With High-Risk Neuroblastoma Keshan Satharasinghe, Toby N. Trahair, Draga Barbaric, Tracey A. O'Brien, Susan J. Russell, Richard J. Cohn, Glenn M. Marshall, and David S. Ziegler JCO Dec 2009: e233–e234. First published on Nov 2 2009; 10.1200/JCO.2009.24.0036. [Full Text] [PDF]

Reply to K. Satharasinghe et al Brian H. Kushner, Kim Kramer, Shakeel Modak, and Nai-Kong V. Cheung JCO Dec 2009: e235. First published on Nov 2 2009; 10.1200/JCO.2009.25.4144. [Full Text] [PDF]

Critical Review of the Determination Process by the Japanese Reviewing Authority in Approving the Additional Efficacy of Fludarabine Phosphate Hiroto Narimatsu, Giichiro Oiso, Shunsuke Ono, and Masahiro Kami JCO Dec 2009: e236–e238. First published on Nov 2 2009; 10.1200/JCO.2009.23.9020. [Full Text] [PDF]

Impact on Cardiac Toxicity With Trastuzumab and Radiotherapy: The Question Is Still Ongoing Nicolas Magné, Lionel Védrine, and Cyrus Chargari JCO Dec 2009: e239. First published on Nov 2 2009; 10.1200/JCO.2009.24.6918. [Full Text] [PDF]

Reply to N. Magné et al Michele Y. Halyard, Thomas M. Pisansky, Amylou C. Dueck, Vera J. Suman, Lori J. Pierce, Lawrence J. Solin, Lawrence B. Marks, Nancy Davidson, Silvana Martino, Peter Kaufman, Leila Kutteh, Shaker Dakhil, and Edith A. Perez JCO Dec 2009: e240–e241. First published on Nov 2 2009; 10.1200/JCO.2009.24.7767. [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.