Journal of Clinical Oncology Early Release Articles

Journal of Clinical Oncology publishes all articles on JCO.org in advance of print publication. The new policy provides subscribers with the latest clinical research several weeks before it appears in print. All articles have been reviewed, copyedited, and typeset, and appear in the final form in which they will appear in the print journal. Once an article appears in print, it will be removed from the Early Release page and grouped with the other contents of the issue in which it appears. All articles below are citable by using the Digital Object Identifier (DOI), a unique number given to every article, and the posting date.

Next posting date: November 30, 2009

Last updated November 23, 2009 [View by date]

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ASCO SPECIAL ARTICLES
ART OF ONCOLOGY
BREAST CANCER
CANCER RELATED COMPLICATIONS
CLINICAL TRIALS
COMMENTS AND CONTROVERSIES
CORRESPONDENCE
DIAGNOSIS IN ONCOLOGY
ECONOMIC ANALYSIS
EDITORIALS
GASTROINTESTINAL CANCER
GENITOURINARY CANCER
GYNECOLOGIC CANCER
HEAD AND NECK CANCER
HEALTH SERVICES AND OUTCOMES
HEMATOLOGIC MALIGNANCIES
MELANOMA
NEUROONCOLOGY
PALLIATIVE AND SUPPORTIVE CARE
PEDIATRIC ONCOLOGY
PHASE I AND CLINICAL PHARMACOLOGY
REVIEW ARTICLES
THORACIC ONCOLOGY
TREATMENT-RELATED COMPLICATIONS

To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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ASCO SPECIAL ARTICLES

American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non–Small-Cell Lung Cancer

Christopher G. Azzoli, Sherman Baker Jr, Sarah Temin, William Pao, Timothy Aliff, Julie Brahmer, David H. Johnson, Janessa L. Laskin, Gregory Masters, Daniel Milton, Luke Nordquist, David G. Pfister, Steven Piantadosi, Joan H. Schiller, Reily Smith, Thomas J. Smith, John R. Strawn, David Trent, and Giuseppe Giaccone
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.23.5622 [Abstract] [PDF] [Additional Resources on ASCO.org]  

Clinical Cancer Advances 2009: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical Oncology

Nicholas J. Petrelli, Eric P. Winer, Julie Brahmer, Sarita Dubey, Sonali Smith, Charles Thomas, Linda T. Vahdat, Jennifer Obel, Nicholas Vogelzang, Maurie Markman, John W. Sweetenham, David Pfister, Mark G. Kris, Lynn M. Schuchter, Raymond Sawaya, Derek Raghavan, Patricia A. Ganz, and Barnett Kramer
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.26.6171 [Abstract] [PDF]  

American Society of Clinical Oncology 2009 Clinical Evidence Review on Radiofrequency Ablation of Hepatic Metastases From Colorectal Cancer

Sandra L. Wong, Pamela B. Mangu, Michael A. Choti, Todd S. Crocenzi, Gerald D. Dodd III, Gary S. Dorfman, Cathy Eng, Yuman Fong, Andrew F. Giusti, David Lu, Thomas A. Marsland, Rob Michelson, Graeme J. Poston, Deborah Schrag, Jerome Seidenfeld, and Al B. Benson III
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.4450 [Abstract] [PDF]  

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ART OF ONCOLOGY

Cancer and the Family: The Silent Words of Truth

Lea Baider and Antonella Surbone
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.25.1223 [Abstract] [PDF]  

Pessimism Is No Poison

Lidia Schapira, Phyllis Butow, Richard Brown, and Frances Boyle
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.25.0027 [Abstract] [PDF]  

Healing by Cancer

Michael Silbermann, Amal Dweib Khleif, and Lodovico Balducci
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.8161 [Abstract] [PDF]  

The Hardest Job in Medicine

Richard C. Frank
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.1371 [Abstract] [PDF]  

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BREAST CANCER

Prognosis of Women With Metastatic Breast Cancer by HER2 Status and Trastuzumab Treatment: An Institutional-Based Review

Shaheenah Dawood, Kristine Broglio, Aman U. Buzdar, Gabriel N. Hortobagyi, and Sharon H. Giordano
JCO published online November 23, 2009, DOI:10.1200/JCO.2008.19.9844 [Abstract] [PDF]  

Contralateral Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Monika K. Graeser, Christoph Engel, Kerstin Rhiem, Dorothea Gadzicki, Ulrich Bick, Karin Kast, Ursula G. Froster, Bettina Schlehe, Astrid Bechtold, Norbert Arnold, Sabine Preisler-Adams, Carolin Nestle-Kraemling, Mohammad Zaino, Markus Loeffler, Marion Kiechle, Alfons Meindl, Dominic Varga, and Rita K. Schmutzler
JCO published online November 23, 2009, DOI:10.1200/JCO.2008.19.9430 [Abstract] [PDF] [Publisher's Note]  

Tumor-Associated Lymphocytes As an Independent Predictor of Response to Neoadjuvant Chemotherapy in Breast Cancer

Carsten Denkert, Sibylle Loibl, Aurelia Noske, Marc Roller, Berit Maria Müller, Martina Komor, Jan Budczies, Silvia Darb-Esfahani, Ralf Kronenwett, Claus Hanusch, Christian von Törne, Wilko Weichert, Knut Engels, Christine Solbach, Iris Schrader, Manfred Dietel, and Gunter von Minckwitz
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.7370 [Abstract] [PDF]  

Tubular Carcinoma of the Breast: Further Evidence to Support Its Excellent Prognosis

Emad A. Rakha, Andrew H.S. Lee, Andrew J. Evans, Sindhu Menon, Nancy Y. Assad, Zsolt Hodi, Douglas Macmillan, Roger W. Blamey, and Ian O. Ellis
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.5051 [Abstract] [PDF]  

Trastuzumab for Patients With Axillary-Node–Positive Breast Cancer: Results of the FNCLCC-PACS 04 Trial

Marc Spielmann, Henri Roché, Thierry Delozier, Jean-Luc Canon, Gilles Romieu, Hugues Bourgeois, Jean-Marc Extra, Daniel Serin, Pierre Kerbrat, Jean-Pascal Machiels, Alain Lortholary, Hubert Orfeuvre, Mario Campone, Anne-Claire Hardy-Bessard, Bruno Coudert, Marie Maerevoet, Gilles Piot, Andrew Kramar, Anne-Laure Martin, and Frédérique Penault-Llorca
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.0946 [Abstract] [PDF]  

Neoadjuvant Chemotherapy Shows Similar Response in Patients With Inflammatory or Locally Advanced Breast Cancer When Compared With Operable Breast Cancer: A Secondary Analysis of the GeparTrio Trial Data

Serban Dan Costa, Sibylle Loibl, Manfred Kaufmann, Dirk-Michael Zahm, Jörn Hilfrich, Jens Huober, Holger Eidtmann, Andreas du Bois, Jens-Uwe Blohmer, Beyhan Ataseven, Erich Weiss, Hans Tesch, Bernd Gerber, Klaus H. Baumann, Christoph Thomssen, Georg Peter Breitbach, Shaip Ibishi, Christian Jackisch, Keyur Mehta, and Gunter von Minckwitz
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.5101 [Abstract] [PDF]  

Cyclophosphamide, Epirubicin, and Fluorouracil Versus Dose-Dense Epirubicin and Cyclophosphamide Followed by Paclitaxel Versus Doxorubicin and Cyclophosphamide Followed by Paclitaxel in Node-Positive or High-Risk Node-Negative Breast Cancer

Margot Burnell, Mark N. Levine, Judith-Anne W. Chapman, Vivien Bramwell, Karen Gelmon, Barbara Walley, Ted Vandenberg, Haji Chalchal, Kathy S. Albain, Edith A. Perez, Hope Rugo, Kathleen Pritchard, Patti O'Brien, and Lois E. Shepherd
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.22.1077 [Abstract] [PDF]  

Conjugated Equine Estrogen Influence on Mammographic Density in Postmenopausal Women in a Substudy of the Women's Health Initiative Randomized Trial

Anne McTiernan, Rowan T. Chlebowski, Christopher Martin, Jennifer David Peck, Aaron Aragaki, Etta D. Pisano, C. Y. Wang, Karen C. Johnson, JoAnn E. Manson, Robert B. Wallace, Mara Z. Vitolins, and Gerardo Heiss
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.21.7166 [Abstract] [PDF]  

Dose-Dense Adjuvant Doxorubicin and Cyclophosphamide Is Not Associated With Frequent Short-Term Changes in Left Ventricular Ejection Fraction

Patrick G. Morris, Maura Dickler, Heather L. McArthur, Tiffany Traina, Steven Sugarman, Nancy Lin, Beverly Moy, Steven Come, Laura Godfrey, Benjamin Nulsen, Carol Chen, Richard Steingart, Hope Rugo, Larry Norton, Eric Winer, Clifford A. Hudis, and Chau T. Dang
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.20.2952 [Abstract] [PDF]  

Y-Box–Binding Protein YB-1 Identifies High-Risk Patients With Primary Breast Cancer Benefiting From Rapidly Cycled Tandem High-Dose Adjuvant Chemotherapy

Oleg Gluz, Karin Mengele, Manfred Schmitt, Ronald Kates, Raihana Diallo-Danebrock, Frauke Neff, Hans-Dieter Royer, Niels Eckstein, Svjetlana Mohrmann, Evelyn Ting, Marion Kiechle, Christopher Poremba, Ulrike Nitz, and Nadia Harbeck
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.19.6261 [Abstract] [PDF]  

Multimodality Screening of High-Risk Women: A Prospective Cohort Study

Susan P. Weinstein, A. Russell Localio, Emily F. Conant, Mark Rosen, Kathleen M. Thomas, and Mitchell D. Schnall
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.4277 [Abstract] [PDF]  

Advanced Breast Cancer and Breast Cancer Mortality in Randomized Controlled Trials on Mammography Screening

Philippe Autier, Clarisse Héry, Jari Haukka, Mathieu Boniol, and Graham Byrnes
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.7041 [Abstract] [PDF]  

One-Year Outcomes of a Behavioral Therapy Intervention Trial on Sleep Quality and Cancer-Related Fatigue

Ann M. Berger, Brett R. Kuhn, Lynne A. Farr, Susanna G. Von Essen, Julie Chamberlain, James C. Lynch, and Sangeeta Agrawal
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.20.8306 [Abstract] [PDF] [Data Supplement]  

Phase II Multicenter Trial of Anthracycline Rechallenge With Pegylated Liposomal Doxorubicin Plus Cyclophosphamide for First-Line Therapy of Metastatic Breast Cancer Previously Treated With Adjuvant Anthracyclines

Maureen E. Trudeau, Mark J. Clemons, Louise Provencher, Lawrence Panasci, Louise Yelle, Daniel Rayson, Jean Latreille, Ted Vandenberg, Rakesh Goel, Labib Zibdawi, Yasmin Rahim, and Jean-Francois Pouliot
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.7504 [Abstract] [PDF]  

Feasibility Trial of Letrozole in Combination With Bevacizumab in Patients With Metastatic Breast Cancer

Tiffany A. Traina, Hope S. Rugo, James F. Caravelli, Sujata Patil, Benjamin Yeh, Michele E. Melisko, John W. Park, Stephanie Geneus, Matthew Paulson, Jill Grothusen, Andrew D. Seidman, Monica Fornier, Diana Lake, Chau Dang, Mark Robson, Maria Theodoulou, Carlos D. Flombaum, Larry Norton, Clifford A. Hudis, and Maura N. Dickler
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.21.8784 [Abstract] [PDF]  

Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

Leisha A. Emens, Justin M. Asquith, James M. Leatherman, Barry J. Kobrin, Silvia Petrik, Marina Laiko, Joy Levi, Maithili M. Daphtary, Barbara Biedrzycki, Antonio C. Wolff, Vered Stearns, Mary L. Disis, Xiaobu Ye, Steven Piantadosi, John H. Fetting, Nancy E. Davidson, and Elizabeth M. Jaffee
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.3494 [Abstract] [PDF]  

Underweight and Breast Cancer Recurrence and Death: A Report From the Korean Breast Cancer Society

Hyeong-Gon Moon, Wonshik Han, and Dong-Young Noh
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.4436 [Abstract] [PDF]  

Novel Breast Tissue Feature Strongly Associated With Risk of Breast Cancer

Kevin P. McKian, Carol A. Reynolds, Daniel W. Visscher, Aziza Nassar, Derek C. Radisky, Robert A. Vierkant, Amy C. Degnim, Judy C. Boughey, Karthik Ghosh, Stephanie S. Anderson, Douglas Minot, Jill L. Caudill, Celine M. Vachon, Marlene H. Frost, V. Shane Pankratz, and Lynn C. Hartmann
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.21.5079 [Abstract] [PDF]  

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CANCER RELATED COMPLICATIONS

Aortic Stiffness Increases Upon Receipt of Anthracycline Chemotherapy

Narumol Chaosuwannakit, Ralph D'Agostino Jr, Craig A. Hamilton, Kimberly S. Lane, William O. Ntim, Julia Lawrence, Susan A. Melin, Leslie R. Ellis, Frank M. Torti, William C. Little, and W. Gregory Hundley
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.8527 [Abstract] [PDF]  

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CLINICAL TRIALS

Differences in Clinical Trial Patient Attributes and Outcomes According to Enrollment Setting

Elizabeth B. Lamont, Mary Beth Landrum, Nancy L. Keating, Laura Archer, Lan Lan, Gary M. Strauss, Rogerio Lilenbaum, Harvey B. Niell, L. Herbert Maurer, Michael P. Kosty, Antonius A. Miller, Gerald H. Clamon, Anthony D. Elias, Edward F. McClay, Everett E. Vokes, and Barbara J. McNeil
JCO published online November 23, 2009, DOI:10.1200/JCO.2008.21.3652 [Abstract] [PDF]  

Role of Sensitivity Analyses in Assessing Progression-Free Survival in Late-Stage Oncology Trials

Suman Bhattacharya, Gwen Fyfe, Robert J. Gray, and Daniel J. Sargent
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.4329 [Abstract] [PDF]  

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COMMENTS AND CONTROVERSIES

To Treat Pelvic Nodes or Not: Could the Greater Testicular Scatter Dose From Whole Pelvic Fields Confound Results of Prostate Cancer Trials?

Christopher R. King and Daniel S. Kapp
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.3808 [Abstract] [PDF]  

Toward Efficient Trials in Colorectal Cancer: The ARCAD Clinical Trials Program

Aimery de Gramont, Daniel G. Haller, Daniel J. Sargent, Josep Tabernero, Alastair Matheson, and Richard L. Schilsky
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.2544 [Abstract] [PDF]  

Incremental Advance or Seismic Shift? The Need to Raise the Bar of Efficacy for Drug Approval

Alberto Sobrero and Paolo Bruzzi
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.4162 [Abstract] [PDF]  

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CORRESPONDENCE

What Is the Appropriate Systemic Chemotherapy for Lymphocyte-Predominant Hodgkin's Lymphoma?

George P. Canellos and Peter Mauch
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.26.3293 [Abstract] [PDF]  

Routine Omission of Sentinel Lymph Node Biopsy for Merkel Cell Carcinoma 1 cm Is Not Justified

Amod A. Sarnaik, Jonathan S. Zager, L. Elizabeth Cox, Tatiana M. Ochoa, Jane L. Messina, and Vernon K. Sondak
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.9937 [Abstract] [PDF]  

Reply to L. de Lima Araujo et al

Egbert F. Smit, Harry J.M. Groen, and Nico van Zandwijk
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.2239 [Abstract] [PDF]  

Platinum-Based Second-Line Treatment in Non–Small-Cell Lung Cancer: An Old New Kid on the Block?

Luiz Henrique de Lima Araújo and Carlos G. Ferreira
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.1157 [Abstract] [PDF]  

Reply to A. Voogd et al

Hans Wildiers, Ben Van Calster, Thijs Van Dorpe, Anne-Sophie Dieudonné, Ann Smeets, Marie-Rose Christiaens, and Patrick Neven
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.25.0548 [Abstract] [PDF]  

Age-Related Variations in the Use of Axillary Staging May Explain the Increased Risk of Axillary Lymph Node Involvement in Older Women With Breast Cancer

Adri C. Voogd, Grard A.P. Nieuwenhuijzen, and Jan Willem W. Coebergh
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.9292 [Abstract] [PDF]  

Clinical Utility of Serum Human Epidermal Growth Factor Receptor 2 Extracellular Domain Levels: Stop the Shilly-Shally—It Is Time for a Well-Designed, Large-Scale Prospective Study

Chantal Tse and Pierre-Jean Lamy
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.5100 [Abstract] [PDF]  

Reply to L.T. Chen et al

Stephen L. Chan, Frankie K. Mo, and Winnie Yeo
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.8667 [Abstract] [PDF]  

Alpha-Fetoprotein Response in Advanced Hepatocellular Carcinoma Receiving Cytostatic Agent

Li-Tzong Chen, Her-Shyong Shiah, Yee Chao, Jang-Yang Chang, Li-Ting Cheng, and Jacqueline Whang-Peng
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.8311 [Abstract] [PDF]  

Reply to S.M. Ali et al

Siân Lennon, Claire Barton, Ludger Banken, Luca Gianni, Michel Marty, Jose Baselga, and Brian Leyland-Jones
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.5903 [Abstract] [PDF]  

Value of Serum Human Epidermal Growth Factor Receptor 2 (HER2)/neu Testing for Early Prediction of Response to HER2/neu-Directed Therapies Is Still an Open One and Deserves Further Study in Large Prospective Trials

Suhail M. Ali, Kim Leitzel, Allan Lipton, Walter P. Carney, and Wolfgang J. Köstler
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.4674 [Abstract] [PDF]  

Reply to C. Kollmannsberger et al

Hua-yin Yu and Christopher S. Saigal
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.8632 [Abstract] [PDF]  

Clinical Claims From Claims-Based Data

Craig R. Nichols and Christian Kollmannsberger
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.8319 [Abstract] [PDF]  

Reply to M. Chao et al

Heidi Nelson, Daniel Sargent, and Vassiliki Tsikitis
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.6669 [Abstract] [PDF]  

Caution Is Required Before Recommending Routine Carcinoembryonic Antigen and Imaging Follow-Up for Patients With Early-Stage Colon Cancer

Michael Chao and Peter Gibbs
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.6156 [Abstract] [PDF]  

Reply to D.L. Raunig

Lori E. Dodd, Edward L. Korn, Boris Freidlin, Lawrence Rubinstein, Janet Dancey, C. Carl Jaffe, and Margaret Mooney
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.4342 [Abstract] [PDF]  

Are Onsite Image Evaluations the Solution or Are We Trading One Problem for Another?

David L. Raunig
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.3716 [Abstract] [PDF]  

Reply to S.J. Faivre et al

Andrew X. Zhu, Dushyant V. Sahani, Dan G. Duda, and Rakesh K. Jain
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.1173 [Abstract] [PDF]  

Sunitinib in Hepatocellular Carcinoma: Redefining Appropriate Dosing, Schedule, and Activity End Points

Sandrine Faivre, Mohamed Bouattour, Chantal Dreyer, and Eric Raymond
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.0670 [Abstract] [PDF]  

Reply to A. Sánchez-Muñoz et al

Filippo Montemurro, Lucia Del Mastro, and Massimo Aglietta
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4326 [Abstract] [PDF]  

Reply to Aragon-Ching

Shabbir M.H. Alibhai
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4300 [Abstract] [PDF]  

Reply to T. Grenader et al

Sao Jiralerspong and Ana M. Gonzalez-Angulo
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4292 [Abstract] [PDF]  

Metformin As an Addition to Conventional Chemotherapy in Breast Cancer

Tal Grenader, Anthony Goldberg, and Linda Shavit
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4110 [Abstract] [PDF]  

Cardiovascular Disease With Androgen Deprivation: The (forgotten) Role of Testosterone

Jeanny B. Aragon-Ching
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4078 [Abstract] [PDF]  

Aromatase Inhibitors As Adjuvant Therapy for Breast Cancer: Overall Survival Versus Disease-Free Survival As a Primary End Point in Clinical Practice

Alfonso Sánchez-Muñoz, Nuria Ribelles, Antonia Márquez, Elisabeth Pérez-Ruiz, and Emilio Alba
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.3914 [Abstract] [PDF]  

Reply to A. Sasse et al

Yu Yang Soon, Martin R. Stockler, Lisa M. Askie, and Michael J. Boyer
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.3757 [Abstract] [PDF]  

Duration of Chemotherapy for Metastatic Non–Small-Cell Lung Cancer: More May Be Not Better

Andre D. Sasse, Joao P. Lima, Emma C. Sasse, and Lucas V. Santos
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.1918 [Abstract] [PDF]  

Reply to Lin et al

Luis Souhami, Kyounghwa Bae, and Howard M. Sandler
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.2221 [Abstract] [PDF]  

Selection Bias Clouds Apparent Benefit of Longer Hormone Duration

Kevin Lin, Steve P. Lee, and Michael L. Steinberg
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0969 [Abstract] [PDF]  

Reply to S. Nagai et al

David Grimwade, Jelena V. Jovanovic, Robert K. Hills, Ellen Solomon, Francesco Lo-Coco, Keith Wheatley, and Alan K. Burnett
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0522 [Abstract] [PDF]  

Revisiting the Concept of Phenotypically Distinct Malignant Pancreatic Stem-Cell Subsets Based on Limiting Dilution Transplantation Assays

Thierry Bonnefoix and Mary Callanan
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0282 [Abstract] [PDF]  

How Should We Prevent Hematologic Relapse of Acute Promyelocytic Leukemia?

Sumimasa Nagai, Tsuyoshi Takahashi, and Mineo Kurokawa
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.9995 [Abstract] [PDF]  

Reply to P. Prassopoulos et al

Shauna L. Hillman and Daniel J. Sargent
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.6736 [Abstract] [PDF]  

Metastatic Disease Response to Treatment: How Many Lesions to Measure?

Panos Prassopoulos and Michael Mantatzis
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.4004 [Abstract] [PDF]  

Reply to V. Arena et al

Stefano Zurrida, Giuseppe Viale, and Umberto Veronesi
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.3253 [Abstract] [PDF]  

Breast Cancer Classification: The Dialogue Is Open

Vincenzo Arena, Ilaria Pennacchia, Giovanni Monego, Arnaldo Carbone, and Arnaldo Capelli
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.2461 [Abstract] [PDF]  

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DIAGNOSIS IN ONCOLOGY

Diffusion Magnetic Resonance Imaging Detects Pathologically Confirmed, Nonenhancing Tumor Progression in a Patient With Recurrent Glioblastoma Receiving Bevacizumab

Elizabeth R. Gerstner, Matthew P. Frosch, and Tracy T. Batchelor
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.0233 [Abstract] [PDF]  

Presentation of Extranodal Natural Killer T-Cell Lymphoma, Nasal Type, With Poorly Circumscribed Erythematous Patches

Laura B. Pincus, James L. Zehnder, Isaac M. Neuhaus, Charalambos Andreadis, and Timothy H. McCalmont
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.3428 [Abstract] [PDF]  

Isolated Ovarian Relapse in a 68-Year-Old Woman With Acute Lymphoblastic Leukemia

Manish Kumar Singhal, Vamshi Krishnan, Sarika Singh, Rajive Kumar, and Vinod Raina
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.1398 [Abstract] [PDF]  

Epstein-Barr Virus–Positive Diffuse Large B-Cell Lymphoma During Therapy With Alemtuzumab for T-Cell Prolymphocytic Leukemia

Aliyah R. Sohani, Judith A. Ferry, Priscilla S. Chang, and Jeremy S. Abramson
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.4194 [Abstract] [PDF]  

Gastric Recurrence of Extramedullary Granulocytic Sarcoma After Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia

E Ryoung Choi, Young Hye Ko, Seok Jin Kim, Jun Ho Jang, Kihyun Kim, Won Ki Kang, Chul Won Jung, and Dong Hwan Kim
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.7560 [Abstract] [PDF]  

Extraosseous Pericardial Ewing's Sarcoma

Fathi Azribi, Albiruni Ryan Abdul Razak, Georgina Bough, Daniela Lee, Ruth Plummer, David Rowe, Nick Bown, Petra Dildey, and Stephen Clark
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.7487 [Abstract] [PDF]  

T-Cell Lymphoblastic Lymphoma of the Sternum

Soheila Zareifar, Mohammad Reza Bordbar, Mehran Karim, Bita Geramizadeh, and Ali Reza Rasekhi
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.4898 [Abstract] [PDF]  

Epstein-Barr Virus–Associated Diffuse Large B-Cell Lymphoma in an Immunocompetent Woman

Olga Pozdnyakova, Paul J. Spieler, John Abraham, Arnold S. Freedman, and Jeffery L. Kutok
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.1423 [Abstract] [PDF]  

Esophageal Carcinoma in a 16-Year-Old Girl 8 Years After Gastrotomy

Onkar Singh, Shilpi Gupta, Praveen Baghel, Sapna Shukla, Dharamdas Paramhans, and Raj K. Mathur
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.3238 [Abstract] [PDF]  

Acute Myeloid Leukemia With Myeloid Sarcoma and Eosinophilia: Prolonged Remission and Molecular Response to Imatinib

Dana Védy, Dominique Muehlematter, Thierry Rausch, Michèle Stalder, Martine Jotterand, and Olivier Spertini
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.6976 [Abstract] [PDF]  

Lymphangioleiomyomatosis: Cause of a Malignant Chylous Pleural Effusion

Izabela Malinowska-Kolodziej, Geraldine Finlay, Gregory Campbell, Maria L. Garcia-Moliner, Barbara Weinstein, Cheryl A. Doughty, Wei Qin, Catherine Butterfield, Sarah Short, Kuniaki Seyama, and David J. Kwiatkowski
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.3890 [Abstract] [PDF]  

Bilateral Occipital Lobe Invasion in Chronic Lymphocytic Leukemia

Tsunayuki Kakimoto, Tomonori Nakazato, Ryuichiro Hayashi, Hiroyuki Hayashi, Norihide Hayashi, Taijiro Ishiyama, Hiroyuki Asada, and Akaru Ishida
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.8436 [Abstract] [PDF]  

Sorafenib-Induced Bilateral Osteonecrosis of Femoral Heads

Marielle Guillet, Thomas Walter, Jean-Yves Scoazec, Thierry Vial, Catherine Lombard-Bohas, and Jérôme Dumortier
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.4252 [Abstract] [PDF]  

Hodgkin's Lymphoma of the Breast

Christopher J. Hoimes, Megan K. Selbst, Nelofar Q. Shafi, Michal G. Rose, and Manuel F. Rosado
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.1613 [Abstract] [PDF]  

Solitary Extramedullary Plasmacytoma of the Vocal Cord in an Adolescent

Issai Vanan, Arlene Redner, Mark Atlas, Lorraine Marin, Prajoy Kadkade, Jela Bandovic, and Elaine S. Jaffe
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.7461 [Abstract] [PDF]  

Bisphosphonate-Related Osteonecrosis of the Jaw and Left Thumb

Raffaele Longo, Maria Angela Castellana, and Giampietro Gasparini
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.4468 [Abstract] [PDF]  

Tracheal Glomangioma in a Patient With Asthma and Chest Pain

Kathryn L. Parker, Michael D. Zervos, Jessica S. Donington, Pratibha S. Shukla, and Costas S. Bizekis
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.7942 [Abstract] [PDF]  

Incidental Detection of Acute Lymphoblastic Leukemia on [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography

Daisuke Ennishi, Yoshinobu Maeda, Masami Niiya, Katsuji Shinagawa, and Mitsune Tanimoto
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.7769 [Abstract] [PDF]  

Paraneoplastic Acrokeratosis (Bazex Syndrome) in Lung Cancer

Antonio Crucitti, Claudio Feliciani, Ugo Grossi, Antonio La Greca, Venanzio Porziella, Piero Giustacchini, Maria Teresa Congedo, Pietrangelo Fronterré, and Pierluigi Maria Granone
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.6852 [Abstract] [PDF]  

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ECONOMIC ANALYSIS

Costs and Benefits of the National Cancer Institute Central Institutional Review Board

Todd H. Wagner, Christine Murray, Jacquelyn Goldberg, Jeanne M. Adler, and Jeffrey Abrams
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.2470 [Abstract] [PDF]  

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EDITORIALS

Generalizing the Results of Cancer Clinical Trials

Ralph M. Meyer
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.8608 [Abstract] [PDF]  

Adjuvant Chemotherapy for Non–Small-Cell Lung Cancer: It Does Not Always Fade With Time

Jean-Yves Douillard
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.5109 [Abstract] [PDF]  

Oropharyngeal Cancer, Human Papilloma Virus, and Clinical Trials

Danny Rischin
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.9045 [Abstract] [PDF]  

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Cancer: A Panacea or Just an Obstacle Course for the Patient?

Vijay P. Khatri
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.8500 [Abstract] [PDF]  

Long-Term Cardiac Safety of Dose-Dense Anthracycline Therapy Cannot Be Predicted From Early Ejection Fraction Data

Michael S. Ewer and Steven M. Ewer
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.5091 [Abstract] [PDF]  

Balancing Efficacy and Safety in the Treatment of Adolescents With Hodgkin's Lymphoma

Monika L. Metzger and Melissa M. Hudson
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.3765 [Abstract] [PDF]  

Anaplastic Gliomas

Lisa M. DeAngelis
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.5985 [Abstract] [PDF]  

The Forest and the Trees: Pathways and Proteins As Colorectal Cancer Biomarkers

Monica M. Bertagnolli
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.8013 [Abstract] [PDF]  

Recognition and Treatment of Sleep Disturbances in Cancer

Sonia Ancoli-Israel
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.5993 [Abstract] [PDF]  

Contralateral Breast Cancer in BRCA1/BRCA2 Mutation Carriers: The Story of the Other Side

Judy E. Garber and Mehra Golshan
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.1652 [Abstract] [PDF]  

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GASTROINTESTINAL CANCER

Daily Oral Everolimus Activity in Patients With Metastatic Pancreatic Neuroendocrine Tumors After Failure of Cytotoxic Chemotherapy: A Phase II Trial

James C. Yao, Catherine Lombard-Bohas, Eric Baudin, Larry K. Kvols, Philippe Rougier, Philippe Ruszniewski, Sakina Hoosen, Jessica St. Peter, Tomas Haas, David Lebwohl, Eric Van Cutsem, Matthew H. Kulke, Timothy J. Hobday, Thomas M. O'Dorisio, Manisha H. Shah, Guillaume Cadiot, Gabriele Luppi, James A. Posey, and Bertram Wiedenmann
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.2669 [Abstract] [PDF]  

Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer

Pierre Laurent-Puig, Anne Cayre, Gilles Manceau, Emmanuel Buc, Jean-Baptiste Bachet, Thierry Lecomte, Philippe Rougier, Astrid Lievre, Bruno Landi, Valérie Boige, Michel Ducreux, Marc Ychou, Fréderic Bibeau, Olivier Bouché, Julia Reid, Steven Stone, and Frédérique Penault-Llorca
JCO published online November 23, 2009, DOI:10.1200/JCO.2008.21.6796 [Abstract] [PDF] [Publisher's Note]  

In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer

Franck Pagès, Amos Kirilovsky, Bernhard Mlecnik, Martin Asslaber, Marie Tosolini, Gabriela Bindea, Christine Lagorce, Philippe Wind, Florence Marliot, Patrick Bruneval, Kurt Zatloukal, Zlatko Trajanoski, Anne Berger, Wolf-Herman Fridman, and Jérôme Galon
JCO published online November 23, 2009, DOI:10.1200/JCO.2008.19.6147 [Abstract] [PDF] [Publisher's Note]  

Peritoneal Colorectal Carcinomatosis Treated With Surgery and Perioperative Intraperitoneal Chemotherapy: Retrospective Analysis of 523 Patients From a Multicentric French Study

Dominique Elias, François Gilly, Florent Boutitie, François Quenet, Jean-Marc Bereder, Baudouin Mansvelt, Gérard Lorimier, Pierre Dubè, and Olivier Glehen
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.9285 [Abstract] [PDF]  

Pancreatic Endocrine Tumors: Expression Profiling Evidences a Role for AKT-mTOR Pathway

Edoardo Missiaglia, Irene Dalai, Stefano Barbi, Stefania Beghelli, Massimo Falconi, Marco della Peruta, Lorenzo Piemonti, Gabriele Capurso, Alessia Di Florio, Gianfranco delle Fave, Paolo Pederzoli, Carlo M. Croce, and Aldo Scarpa
JCO published online November 16, 2009, DOI:10.1200/JCO.2008.21.5988 [Abstract] [PDF]  

Nodal Staging Score: A Tool to Assess Adequate Staging of Node-Negative Colon Cancer

Mithat Gönen, Deborah Schrag, and Martin R. Weiser
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.7958 [Abstract] [PDF]  

Unique Localization of Circulating Tumor Cells in Patients With Hepatic Metastases

Long R. Jiao, Christos Apostolopoulos, Jimmy Jacob, Richard Szydlo, Natalia Johnson, Nicole Tsim, Nagy A. Habib, R. Charles Coombes, and Justin Stebbing
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.5837 [Abstract] [PDF]  

KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial

Susan D. Richman, Matthew T. Seymour, Philip Chambers, Faye Elliott, Catherine L. Daly, Angela M. Meade, Graham Taylor, Jennifer H. Barrett, and Philip Quirke
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.4295 [Abstract] [PDF]  

Practical Application of a Calculator for Conditional Survival in Colon Cancer

George J. Chang, Chung-Yuan Hu, Cathy Eng, John M. Skibber, and Miguel A. Rodriguez-Bigas
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.1860 [Abstract] [PDF]  

Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer

John A. Chabot, Wei-Yann Tsai, Robert L. Fine, Chunxia Chen, Carolyn K. Kumah, Karen A. Antman, and Victor R. Grann
JCO published online August 17, 2009, DOI:10.1200/JCO.2009.22.8429 [Abstract] [PDF]  

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GENITOURINARY CANCER

Evaluating Overall Survival and Competing Risks of Death in Patients With Localized Renal Cell Carcinoma Using a Comprehensive Nomogram

Alexander Kutikov, Brian L. Egleston, Yu-Ning Wong, and Robert G. Uzzo
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.22.4816 [Abstract] [PDF]  

Clinical Results of Long-Term Follow-Up of a Large, Active Surveillance Cohort With Localized Prostate Cancer

Laurence Klotz, Liying Zhang, Adam Lam, Robert Nam, Alexandre Mamedov, and Andrew Loblaw
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.2180 [Abstract] [PDF]  

Defining the Optimal Treatment for Clinical Stage I Nonseminomatous Germ Cell Testicular Cancer Using Decision Analysis

Carvell T. Nguyen, Alex Z. Fu, Timothy D. Gilligan, Brian J. Wells, Eric A. Klein, Michael W. Kattan, and Andrew J. Stephenson
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.22.0400 [Abstract] [PDF]  

Evaluating the Combined Effect of Comorbidity and Prostate-Specific Antigen Kinetics on the Risk of Death in Men After Prostate-Specific Antigen Recurrence

Jennifer Y. Wo, Ming-Hui Chen, Paul L. Nguyen, Andrew A. Renshaw, Marian J. Loffredo, Philip W. Kantoff, and Anthony V. D'Amico
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.6067 [Abstract] [PDF]  

Health-Related Quality of Life in Long-Term Survivors of Testicular Cancer

Philip Blach Rossen, Anette Fischer Pedersen, Robert Zachariae, and Hans von der Maase
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.19.6931 [Abstract] [PDF]  

Randomized Phase III Trial on Gemcitabine Versus Mytomicin in Recurrent Superficial Bladder Cancer: Evaluation of Efficacy and Tolerance

Raffaele Addeo, Michele Caraglia, Sergio Bellini, Alberto Abbruzzese, Bruno Vincenzi, Liliana Montella, Antonio Miragliuolo, Rosario Guarrasi, Michele Lanna, Gregorio Cennamo, Vincenzo Faiola, and Salvatore Del Prete
JCO published online October 19, 2009, DOI:10.1200/JCO.2008.20.8199 [Abstract] [PDF]  

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GYNECOLOGIC CANCER

Phase II Clinical Trial of Ixabepilone in Patients With Recurrent or Persistent Platinum- and Taxane-Resistant Ovarian or Primary Peritoneal Cancer: A Gynecologic Oncology Group Study

Koen De Geest, John A. Blessing, Robert T. Morris, S. Diane Yamada, Bradley J. Monk, Susan L. Zweizig, Daniela Matei, Carolyn Y. Muller, and William E. Richards
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.1455 [Abstract] [PDF]  

Phase II Study of Carboplatin, Paclitaxel, and Bevacizumab With Maintenance Bevacizumab As First-Line Chemotherapy for Advanced Müllerian Tumors

Richard T. Penson, Don S. Dizon, Stephen A. Cannistra, Maria R. Roche, Carolyn N. Krasner, Suzanne T. Berlin, Neil S. Horowitz, Paul A. DiSilvestro, Ursula A. Matulonis, Hang Lee, Modjulie A. King, and Susana M. Campos
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.22.7900 [Abstract] [PDF]  

Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Sharmila Makhija, Lukas C. Amler, Dana Glenn, Frederick R. Ueland, Michael A. Gold, Don S. Dizon, Virginia Paton, Chin-Yu Lin, Thomas Januario, Kimmie Ng, Andreas Strauss, Stephen Kelsey, Mark X. Sliwkowski, and Ursula Matulonis
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.22.3354 [Abstract] [PDF]  

Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes

Kristel Van Calsteren, Liesbeth Heyns, Frank De Smet, Liesbet Van Eycken, Mina Mhallem Gziri, Willemijn Van Gemert, Michael Halaska, Ignace Vergote, Nelleke Ottevanger, and Frédéric Amant
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.2801 [Abstract] [PDF]  

Preventing Future Cancers by Testing Women With Ovarian Cancer for BRCA Mutations

Janice S. Kwon, Molly S. Daniels, Charlotte C. Sun, and Karen H. Lu
JCO published online October 19, 2009, DOI:10.1200/JCO.2008.21.4684 [Abstract] [PDF]  

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HEAD AND NECK CANCER

Predictors of Competing Mortality in Advanced Head and Neck Cancer

Loren K. Mell, James J. Dignam, Joseph K. Salama, Ezra E.W. Cohen, Blase N. Polite, Virag Dandekar, Amit D. Bhate, Mary Ellyn Witt, Daniel J. Haraf, Bharat B. Mittal, Everett E. Vokes, and Ralph R. Weichselbaum
JCO published online November 23, 2009, DOI:10.1200/JCO.2008.20.9288 [Abstract] [PDF]  

Phase II Study of Sunitinib in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: GORTEC 2006-01

Jean-Pascal H. Machiels, Stéphanie Henry, Sylvie Zanetta, Marie-Christine Kaminsky, Nicolas Michoux, Denis Rommel, Sandra Schmitz, Emmanuelle Bompas, Anne-Françoise Dillies, Sandrine Faivre, Anne Moxhon, Thierry Duprez, and Joel Guigay
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.8584 [Abstract] [PDF]  

-Tubulin-II Expression Strongly Predicts Outcome in Patients Receiving Induction Chemotherapy for Locally Advanced Squamous Carcinoma of the Head and Neck: A Companion Analysis of the TAX 324 Trial

Kevin J. Cullen, Lisa Schumaker, Nikolaos Nikitakis, Olga Goloubeva, Ming Tan, Nicholas J. Sarlis, Robert I. Haddad, and Marshall R. Posner
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.0953 [Abstract] [PDF]  

Induction Chemotherapy and Cetuximab for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Results From a Phase II Prospective Trial

Merrill S. Kies, Floyd Christopher Holsinger, J. Jack Lee, William N. William Jr, Bonnie S. Glisson, Heather Y. Lin, Jan S. Lewin, Lawrence E. Ginsberg, Katharine A. Gillaspy, Erminia Massarelli, Lauren Byers, Scott M. Lippman, Waun K. Hong, Adel K. El-Naggar, Adam S. Garden, and Vassiliki Papadimitrakopoulou
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.0425 [Abstract] [PDF]  

Comparative Prognostic Value of HPV16 E6 mRNA Compared With In Situ Hybridization for Human Oropharyngeal Squamous Carcinoma

Wei Shi, Hisayuki Kato, Bayardo Perez-Ordonez, Melania Pintilie, Shaohui Huang, Angela Hui, Brian O'Sullivan, John Waldron, Bernard Cummings, John Kim, Jolie Ringash, Laura A. Dawson, Patrick Gullane, Lillian Siu, Maura Gillison, and Fei-Fei Liu
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.1670 [Abstract] [PDF]  

Reporting of Time-to-Event End Points and Tracking of Failures in Randomized Trials of Radiotherapy With or Without Any Concomitant Anticancer Agent for Locally Advanced Head and Neck Cancer

Christophe Le Tourneau, Stefan Michiels, Hui K. Gan, and Lillian L. Siu
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.3685 [Abstract] [PDF]  

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HEALTH SERVICES AND OUTCOMES

Physician Referral for Fertility Preservation in Oncology Patients: A National Study of Practice Behaviors

Gwendolyn P. Quinn, Susan T. Vadaparampil, Ji-Hyun Lee, Paul B. Jacobsen, Gerold Bepler, Johnathan Lancaster, David L. Keefe, and Terrance L. Albrecht
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.0250 [Abstract] [PDF] [Data Supplement]  

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HEMATOLOGIC MALIGNANCIES

Immunoglobulin G Fc Receptor FcRIIIa 158 V/F Polymorphism Correlates With Rituximab-Induced Neutropenia After Autologous Transplantation in Patients With Non-Hodgkin's Lymphoma

Wen-Kai Weng, Robert S. Negrin, Philip Lavori, and Sandra J. Horning
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.0274 [Abstract] [PDF]  

Early-Stage, Lymphocyte-Predominant Hodgkin's Lymphoma: Patient Outcomes From a Large, Single-Institution Series With Long Follow-Up

Ronald C. Chen, Michael S. Chin, Andrea K. Ng, Yang Feng, Donna Neuberg, Barbara Silver, Geraldine S. Pinkus, Mary Ann Stevenson, and Peter M. Mauch
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.0945 [Abstract] [PDF]  

Immunochemotherapy and Autologous Stem-Cell Transplantation for Untreated Patients With Mantle-Cell Lymphoma: CALGB 59909

Lloyd E. Damon, Jeffrey L. Johnson, Donna Niedzwiecki, Bruce D. Cheson, David D. Hurd, Nancy L. Bartlett, Ann S. LaCasce, Kristie A. Blum, John C. Byrd, Michael Kelly, Wendy Stock, Charles A. Linker, and George P. Canellos
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.22.2554 [Abstract] [PDF]  

Mutations of E3 Ubiquitin Ligase Cbl Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies

Hideki Makishima, Heather Cazzolli, Hadrian Szpurka, Andrew Dunbar, Ramon Tiu, Jungwon Huh, Hideki Muramatsu, Christine O'Keefe, Eric Hsi, Ronald L. Paquette, Seiji Kojima, Alan F. List, Mikkael A. Sekeres, Michael A. McDevitt, and Jaroslaw P. Maciejewski
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.7503 [Abstract] [PDF]  

Survival Effect of Venous Thromboembolism in Patients With Multiple Myeloma Treated With Lenalidomide and High-Dose Dexamethasone

Maurizio Zangari, Guido Tricot, Latha Polavaram, Fenghuang Zhan, Ashlie Finlayson, Robert Knight, Tommy Fu, Donna Weber, Meletios A. Dimopoulos, Ruben Niesvizky, and Louis Fink
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.0169 [Abstract] [PDF]  

Hodgkin's Lymphoma in Adolescents Treated With Adult Protocols: A Report From the German Hodgkin Study Group

Dennis A. Eichenauer, Henning Bredenfeld, Heinz Haverkamp, Horst Müller, Jeremy Franklin, Michael Fuchs, Peter Borchmann, Hans-Konrad Müller-Hermelink, Hans T. Eich, Rolf-Peter Müller, Volker Diehl, and Andreas Engert
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.20.2655 [Abstract] [PDF]  

Phase II Trial of Concurrent Radiation and Weekly Cisplatin Followed by VIPD Chemotherapy in Newly Diagnosed, Stage IE to IIE, Nasal, Extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma Study

Seok Jin Kim, Kihyun Kim, Byung Soo Kim, Chul Yong Kim, Cheolwon Suh, Jooryung Huh, Sang-Wook Lee, Jin Seok Kim, Jaeho Cho, Gyeong-Won Lee, Ki Mun Kang, Hyeon Seok Eom, Hong Ryull Pyo, Yong Chan Ahn, Young Hyeh Ko, and Won Seog Kim
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.8592 [Abstract] [PDF]  

Do Male Lymphoma Survivors Have Impaired Sexual Function?

Cecilie E. Kiserud, Leslie R. Schover, Alv A. Dahl, Alexander Fosså, Trine Bjøro, Jon Håvard Loge, Harald Holte, Ying Yuan, and Sophie D. Fosså
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.2280 [Abstract] [PDF]  

Quantitative PCR Analysis for Bcl-2/IgH in a Phase III Study of Yttrium-90 Ibritumomab Tiuxetan As Consolidation of First Remission in Patients With Follicular Lymphoma

Lindsey Goff, Karin Summers, Sameena Iqbal, Jens Kuhlmann, Michael Kunz, Tom Louton, Anton Hagenbeek, Franck Morschhauser, Barbara Putz, Andrew Lister, and Ama Rohatiner
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.6258 [Abstract] [PDF]  

VMP (Bortezomib, Melphalan, and Prednisone) Is Active and Well Tolerated in Newly Diagnosed Patients With Multiple Myeloma With Moderately Impaired Renal Function, and Results in Reversal of Renal Impairment: Cohort Analysis of the Phase III VISTA Study

Meletios A. Dimopoulos, Paul G. Richardson, Rudolf Schlag, Nuriet K. Khuageva, Ofer Shpilberg, Efstathios Kastritis, Martin Kropff, Maria T. Petrucci, Michel Delforge, Julia Alexeeva, Rik Schots, Tamás Masszi, Maria-Victoria Mateos, William Deraedt, Kevin Liu, Andrew Cakana, Helgi van de Velde, and Jesús F. San Miguel
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.2232 [Abstract] [PDF]  

Phase II Study of Flavopiridol in Relapsed Chronic Lymphocytic Leukemia Demonstrating High Response Rates in Genetically High-Risk Disease

Thomas S. Lin, Amy S. Ruppert, Amy J. Johnson, Beth Fischer, Nyla A. Heerema, Leslie A. Andritsos, Kristie A. Blum, Joseph M. Flynn, Jeffrey A. Jones, Weihong Hu, Mollie E. Moran, Sarah M. Mitchell, Lisa L. Smith, Amy J. Wagner, Chelsey A. Raymond, Larry J. Schaaf, Mitch A. Phelps, Miguel A. Villalona-Calero, Michael R. Grever, and John C. Byrd
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.6944 [Abstract] [PDF]  

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MELANOMA

Final Version of 2009 AJCC Melanoma Staging and Classification

Charles M. Balch, Jeffrey E. Gershenwald, Seng-jaw Soong, John F. Thompson, Michael B. Atkins, David R. Byrd, Antonio C. Buzaid, Alistair J. Cochran, Daniel G. Coit, Shouluan Ding, Alexander M. Eggermont, Keith T. Flaherty, Phyllis A. Gimotty, John M. Kirkwood, Kelly M. McMasters, Martin C. Mihm Jr, Donald L. Morton, Merrick I. Ross, Arthur J. Sober, and Vernon K. Sondak
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.4799 [Abstract] [PDF]  

Phase II Multicenter Trial of Maintenance Biotherapy After Induction Concurrent Biochemotherapy for Patients With Metastatic Melanoma

Steven J. O'Day, Michael B. Atkins, Peter Boasberg, He-Jing Wang, John A. Thompson, Clay M. Anderson, Rene Gonzalez, Jose Lutzky, Thomas Amatruda, Evan M. Hersh, and Jeffrey S. Weber
JCO published online November 16, 2009, DOI:10.1200/JCO.2008.20.3075 [Abstract] [PDF]  

Analysis of Factors Influencing Outcome in Patients With In-Transit Malignant Melanoma Undergoing Isolated Limb Perfusion Using Modern Treatment Parameters

H. Richard Alexander Jr, Douglas L. Fraker, David L. Bartlett, Steven K. Libutti, Seth M. Steinberg, Perry Soriano, and Tatiana Beresnev
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.7511 [Abstract] [PDF]  

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NEUROONCOLOGY

MGMT Promoter Methylation Is Prognostic but Not Predictive for Outcome to Adjuvant PCV Chemotherapy in Anaplastic Oligodendroglial Tumors: A Report From EORTC Brain Tumor Group Study 26951

Martin J. van den Bent, Hendrikus J. Dubbink, Marc Sanson, Cathleen R. van der Lee-Haarloo, Monika Hegi, Judith W.M. Jeuken, Ahmed Ibdaih, Alba A. Brandes, Martin J.B. Taphoorn, Marc Frenay, Denis Lacombe, Thierry Gorlia, Winand N.M. Dinjens, and Johan M. Kros
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.1034 [Abstract] [PDF]  

NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

Wolfgang Wick, Christian Hartmann, Corinna Engel, Mandy Stoffels, Jörg Felsberg, Florian Stockhammer, Michael C. Sabel, Susanne Koeppen, Ralf Ketter, Richard Meyermann, Marion Rapp, Christof Meisner, Rolf D. Kortmann, Torsten Pietsch, Otmar D. Wiestler, Ulrike Ernemann, Michael Bamberg, Guido Reifenberger, Andreas von Deimling, and Michael Weller
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.6497 [Abstract] [PDF]  

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PALLIATIVE AND SUPPORTIVE CARE

Paradoxes in Advance Care Planning: The Complex Relationship of Oncology Patients, Their Physicians, and Advance Medical Directives

Lindsay A. Dow, Robin K. Matsuyama, V. Ramakrishnan, Laura Kuhn, Elizabeth B. Lamont, Laurel Lyckholm, and Thomas J. Smith
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.6397 [Abstract] [PDF]  

Impact of Two Supportive Care Interventions on Anxiety, Depression, Quality of Life, and Unmet Needs in Patients With Nonlocalized Breast and Colorectal Cancers

Afaf Girgis, Sibilah Breen, Fiona Stacey, and Christophe Lecathelinais
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.22.8718 [Abstract] [PDF]  

Effectiveness of a Home Care Nursing Program in the Symptom Management of Patients With Colorectal and Breast Cancer Receiving Oral Chemotherapy: A Randomized, Controlled Trial

Alex Molassiotis, Sarah Brearley, Mark Saunders, Olive Craven, Andrew Wardley, Carole Farrell, Ric Swindell, Chris Todd, and Karen Luker
JCO published online November 16, 2009, DOI:10.1200/JCO.2008.20.6755 [Abstract] [PDF]  

Phase III, Randomized, Double-Blind, Placebo-Controlled Evaluation of Pregabalin for Alleviating Hot Flashes, N07C1

Charles L. Loprinzi, Rui Qin, Ernie P. Baclueva, Kathleen A. Flynn, Kendrith M. Rowland Jr, David L. Graham, Nancy K. Erwin, Shaker R. Dakhil, Donald J. Jurgens, and Kelli N. Burger
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.5647 [Abstract] [PDF]  

Care for Imminently Dying Cancer Patients: Family Members' Experiences and Recommendations

Takuya Shinjo, Tatsuya Morita, Kei Hirai, Mitsunori Miyashita, Kazuki Sato, Satoru Tsuneto, and Yasuo Shima
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.2793 [Abstract] [PDF]  

Patients' Supportive Care Needs Beyond the End of Cancer Treatment: A Prospective, Longitudinal Survey

Jo Armes, Maggie Crowe, Lynne Colbourne, Helen Morgan, Trevor Murrells, Catherine Oakley, Nigel Palmer, Emma Ream, Annie Young, and Alison Richardson
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.5151 [Abstract] [PDF]  

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PEDIATRIC ONCOLOGY

Late-Occurring Neurologic Sequelae in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study

Robert E. Goldsby, Qi Liu, Paul C. Nathan, Daniel C. Bowers, Amanda Yeaton-Massey, Shannon H. Raber, Daniel Hill, Gregory T. Armstrong, Yutaka Yasui, Lonnie Zeltzer, Leslie L. Robison, and Roger J. Packer
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.22.5060 [Abstract] [PDF]  

Infantile Fibrosarcoma: Management Based on the European Experience

Daniel Orbach, Annie Rey, Giovanni Cecchetto, Odile Oberlin, Michela Casanova, Estelle Thebaud, Marcelo Scopinaro, Gianni Bisogno, Modesto Carli, and Andrea Ferrari
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.21.9972 [Abstract] [PDF]  

Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

Lisa R. Treviño, Noriko Shimasaki, Wenjian Yang, John C. Panetta, Cheng Cheng, Deqing Pei, Diana Chan, Alex Sparreboom, Kathleen M. Giacomini, Ching-Hon Pui, William E. Evans, and Mary V. Relling
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.20.4156 [Abstract] [PDF] [Data Supplement]  

Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia

Nina S. Kadan-Lottick, Pim Brouwers, David Breiger, Thomas Kaleita, James Dziura, Veronika Northrup, Lu Chen, Megan Nicoletti, Bruce Bostrom, Linda Stork, and Joseph P. Neglia
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.5408 [Abstract] [PDF]  

Suicide Ideation in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Christopher J. Recklitis, Lisa R. Diller, Xiaochun Li, Julie Najita, Leslie L. Robison, and Lonnie Zeltzer
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.22.8635 [Abstract] [PDF]  

Outcome of Patients Treated for Relapsed or Refractory Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia Consortium Study

Richard H. Ko, Lingyun Ji, Phillip Barnette, Bruce Bostrom, Raymond Hutchinson, Elizabeth Raetz, Nita L. Seibel, Clare J. Twist, Elena Eckroth, Richard Sposto, Paul S. Gaynon, and Mignon L. Loh
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.22.2950 [Abstract] [PDF]  

"Trying to Be a Good Parent" As Defined By Interviews With Parents Who Made Phase I, Terminal Care, and Resuscitation Decisions for Their Children

Pamela S. Hinds, Linda L. Oakes, Judy Hicks, Brent Powell, Deo Kumar Srivastava, Sheri L. Spunt, JoAnn Harper, Justin N. Baker, Nancy K. West, and Wayne L. Furman
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.20.0204 [Abstract] [PDF]  

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PHASE I AND CLINICAL PHARMACOLOGY

Phase I Clinical and Pharmacokinetic Study of Oral Sapacitabine in Patients With Acute Leukemia and Myelodysplastic Syndrome

Hagop Kantarjian, Guillermo Garcia-Manero, Susan O'Brien, Stefan Faderl, Farhad Ravandi, Robert Westwood, Simon R. Green, Judy H. Chiao, Patricia A. Boone, Jorge Cortes, and William Plunkett
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.0209 [Abstract] [PDF]  

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REVIEW ARTICLES

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

Michele Baccarani, Jorge Cortes, Fabrizio Pane, Dietger Niederwieser, Giuseppe Saglio, Jane Apperley, Francisco Cervantes, Michael Deininger, Alois Gratwohl, François Guilhot, Andreas Hochhaus, Mary Horowitz, Timothy Hughes, Hagop Kantarjian, Richard Larson, Jerald Radich, Bengt Simonsson, Richard T. Silver, John Goldman, and Rudiger Hehlmann
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.0779 [Abstract] [PDF]  

Application of Screening Principles to the Reconstructed Breast

Jennifer Zakhireh, Barbara Fowble, and Laura J. Esserman
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.7588 [Abstract] [PDF]  

Ultimate Fate of Oncology Drugs Approved by the US Food and Drug Administration Without a Randomized Trial

Apostolia-Maria Tsimberidou, Fadi Braiteh, David J. Stewart, and Razelle Kurzrock
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.6018 [Abstract] [PDF]  

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THORACIC ONCOLOGY

Phase I Study of Accelerated Conformal Radiotherapy for Stage I Non–Small-Cell Lung Cancer in Patients With Pulmonary Dysfunction: CALGB 39904

Jeffrey A. Bogart, Lydia Hodgson, Stephen L. Seagren, A. William Blackstock, Xiaofei Wang, Robert Lenox, Andrew T. Turrisi III, John Reilly, Ajeet Gajra, Everett E. Vokes, and Mark R. Green
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.0753 [Abstract] [PDF]  

Carboplatin and Paclitaxel in Combination With Either Vorinostat or Placebo for First-Line Therapy of Advanced Non–Small-Cell Lung Cancer

Suresh S. Ramalingam, Michael L. Maitland, Paul Frankel, Athanassios E. Argiris, Marianna Koczywas, Barbara Gitlitz, Sachdev Thomas, Igor Espinoza-Delgado, Everett E. Vokes, David R. Gandara, and Chandra P. Belani
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.9094 [Abstract] [PDF]  

Randomized Phase III Trial of Vinorelbine Plus Cisplatin Compared With Observation in Completely Resected Stage IB and II Non–Small-Cell Lung Cancer: Updated Survival Analysis of JBR-10

Charles A. Butts, Keyue Ding, Lesley Seymour, Philip Twumasi-Ankrah, Barbara Graham, David Gandara, David H. Johnson, Kenneth A. Kesler, Mark Green, Mark Vincent, Yvon Cormier, Glenwood Goss, Brian Findlay, Michael Johnston, Ming-Sound Tsao, and Frances A. Shepherd
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.0333 [Abstract] [PDF]  

Long-Term Results of the International Adjuvant Lung Cancer Trial Evaluating Adjuvant Cisplatin-Based Chemotherapy in Resected Lung Cancer

Rodrigo Arriagada, Ariane Dunant, Jean-Pierre Pignon, Bengt Bergman, Mariusz Chabowski, Dominique Grunenwald, Miroslaw Kozlowski, Cécile Le Péchoux, Robert Pirker, Maria-Izabel Sathler Pinel, Michèle Tarayre, and Thierry Le Chevalier
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.23.2272 [Abstract] [PDF]  

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma: Multi-Institutional Experience

Tristan D. Yan, Marcello Deraco, Dario Baratti, Shigeki Kusamura, Dominique Elias, Olivier Glehen, François N. Gilly, Edward A. Levine, Perry Shen, Faheez Mohamed, Brendan J. Moran, David L. Morris, Terence C. Chua, Pompiliu Piso, and Paul H. Sugarbaker
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.23.9640 [Abstract] [PDF]  

Randomized, Double-Blind Trial of Carboplatin and Paclitaxel With Either Daily Oral Cediranib or Placebo in Advanced Non–Small-Cell Lung Cancer: NCIC Clinical Trials Group BR24 Study

Glenwood D. Goss, Andrew Arnold, Frances A. Shepherd, Mircea Dediu, Tudor-Eliade Ciuleanu, David Fenton, Mauro Zukin, David Walde, Francis Laberge, Mark D. Vincent, Peter M. Ellis, Scott A. Laurie, Keyue Ding, Eliot Frymire, Isabelle Gauthier, Natasha B. Leighl, Cheryl Ho, Jonathan Noble, Christopher W. Lee, and Lesley Seymour
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.22.9427 [Abstract] [PDF]  

Tracheoesophageal Fistula Formation in Patients With Lung Cancer Treated With Chemoradiation and Bevacizumab

David R. Spigel, John D. Hainsworth, Denise A. Yardley, Eric Raefsky, Jeffrey Patton, Nancy Peacock, Cindy Farley, Howard A. Burris III, and F. Anthony Greco
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.7353 [Abstract] [PDF]  

Phase II Study of Preoperative Gefitinib in Clinical Stage I Non–Small-Cell Lung Cancer

Humberto Lara-Guerra, Thomas K. Waddell, Maria A. Salvarrey, Anthony M. Joshua, Catherine T. Chung, Narinder Paul, Scott Boerner, Akira Sakurada, Olga Ludkovski, Clement Ma, Jeremy Squire, Geoffrey Liu, Frances A. Shepherd, Ming-Sound Tsao, and Natasha B. Leighl
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.3370 [Abstract] [PDF]  

Phase II Study of Cisplatin Plus Etoposide and Bevacizumab for Previously Untreated, Extensive-Stage Small-Cell Lung Cancer: Eastern Cooperative Oncology Group Study E3501

Leora Horn, Suzanne E. Dahlberg, Alan B. Sandler, Afshin Dowlati, Dennis F. Moore, John R. Murren, and Joan H. Schiller
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.7545 [Abstract] [PDF] [Publisher's Note]  

Phase II Trial of Pemetrexed Plus Bevacizumab for Second-Line Therapy of Patients With Advanced Non–Small-Cell Lung Cancer: NCCTG and SWOG Study N0426

Alex A. Adjei, Sumithra J. Mandrekar, Grace K. Dy, Julian R. Molina, Araba A. Adjei, David R. Gandara, Katie L. Allen Ziegler, Philip J. Stella, Kendrith M. Rowland Jr, Steven E. Schild, and Ralph G. Zinner
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.6406 [Abstract] [PDF]  

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TREATMENT-RELATED COMPLICATIONS

Cytidine Deaminase Residual Activity in Serum Is a Predictive Marker of Early Severe Toxicities in Adults After Gemcitabine-Based Chemotherapies

Joseph Ciccolini, Laetitia Dahan, Nicolas André, Alexandre Evrard, Muriel Duluc, Aurore Blesius, Chenguang Yang, Sarah Giacometti, Caroline Brunet, Caroline Raynal, Adrien Ortiz, Nicolas Frances, Athanassios Iliadis, Florence Duffaud, Jean-François Seitz, and Cédric Mercier
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.4491 [Abstract] [PDF]  

Prevalence, Demographics, and Psychological Associations of Sleep Disruption in Patients With Cancer: University of Rochester Cancer Center–Community Clinical Oncology Program

Oxana G. Palesh, Joseph A. Roscoe, Karen M. Mustian, Thomas Roth, Josée Savard, Sonia Ancoli-Israel, Charles Heckler, Jason Q. Purnell, Michelle C. Janelsins, and Gary R. Morrow
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.22.5011 [Abstract] [PDF]  

Effective Strategies for Management of Hypertension After Vascular Endothelial Growth Factor Signaling Inhibition Therapy: Results From a Phase II Randomized, Factorial, Double-Blind Study of Cediranib in Patients With Advanced Solid Tumors

Marlies H.G. Langenberg, Carla M.L. van Herpen, Johann De Bono, Jan H.M. Schellens, Clemens Unger, Klaas Hoekman, Hubert E. Blum, Walter Fiedler, Joachim Drevs, Florence Le Maulf, Anitra Fielding, Jane Robertson, and Emile E. Voest
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.22.2273 [Abstract] [PDF]  

Clinically Driven Diagnostic Antifungal Approach in Neutropenic Patients: A Prospective Feasibility Study

Corrado Girmenia, Alessandra Micozzi, Giuseppe Gentile, Stefania Santilli, Eva Arleo, Luisa Cardarelli, Saveria Capria, Clara Minotti, Claudio Cartoni, Simonetta Brocchieri, Vito Guerrisi, Giovanna Meloni, Robin Foà, and Pietro Martino
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.21.8032 [Abstract] [PDF]  

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